Overview and History of DNA Typing

DNA profiling was first described in 1985 by who?

Alec Jeffreys

VNTRs

variable nuymber of tandem repeats (DNA repeat regions

RFLPs

restrictions fragment length polymorphism (use of a restriction enzyme to cut the regions of DNA surrounding the VNTRs)

Do current DNA test based on STR markers look at genes?

No

Applications for humans identity testing using STR markers

parentage analysis to help identify a child’s father

disaster victim identification to literally help put the pieces back together after a major natural or man-made disaster

genetic genealogy and ancestry test to attempt to gain a better understanding of one’s heritage

historical and missing persons investigations to help link recovered bones from unknown individuals back to their family members

Context of a DNA profile

Q (questioned) - sample in question

K (Known) - reference sample

Forensics comparison

kinship comparisons

Q - K Comparison Results

Inclusion/Association (match)

Exclusion (no match)

Inconclusive