protese/fusion/CCR5 (HIV and AIDS) antivirals

the acronym for protease inhibitors is

FRTND (friend)

the prototype for protease inhibitors are

fosamprenavir

the protease inhibitor fosamprenavir works by

inhibiting protease, causing immature particles

fosamprenavir is specifically used for

symptomatic HIV only

the second protease inhibitor is

ritonavir

ritonavir is specifically a combo drug that can have

toxic effect when taken with non sedating enzymes, antihistamines, hypnotics, antiarrythmics

the third protease inhibitor is

tipranavir

tipranavir must be given with

• high doses of ritonavir

• food

the usage of tipranavir can lead to

toxic liver dysfunction

the fourth protease inhibitor is

nelfinavir

the protease inhibitor nelfinavir is (good) and can be taken in patients who have

renal impairments

the final protease inhibitor is

darvunavir

the protease inhibitor darunavir is known for causing

• hyperglycemia

• DM

• steven johnson syndrome

it is critcal that all protease inhibitors are not taken with

• grapefruit jucie

• seizure meds

• st.john wort

protease inhibitors cause an increase in

• triglycerides

• cholesterol

that can lead to a redistribution of body fat

all protease inhibitors can be used in

both adults and children

protease inhibitors can not be taken in patients who have

DM

all protease inhibitors can lead to

steven johnson syndrome

the general purpose of all protease inhibitors is to

prevent maturation of diseased cells

the prototype and only fusion drug is

enfuvirtide

enfuvurtide works by

preventing HIV entry into cells and inhibiting membrane fusion

enfuvirtide should only be used if

other HIV and AIDs treatments have failed

enfuvirtide can cause patients to have

• pnumonia

• chills

one odd fact regarding enfuvirtide is that it is

not excreted at all

along side it being a last resort treatment enfuvirtide should only be given if the patient is

having evident viral replication

if a patinet is taking enfuvirtide they may expereice

• insomnia

• depression

• peripheral neuropathy

the one and only CCR5 drug is

maraviroc

the CCR5 inhibitor maraviroc works by

preventing the interaction between CCR5 and HIV1

one specific thing about the mechanism of CCR5 is that it

cannot enter the cell or multiply

the CCR5 medication maraviroc is used for people who are

evident of viral replication and HIV 1 strains that are resisitant to all other antiretroviral agents

maraviroc can cause a patient to expereice

• paresthesia

• URI/ fever/ cough

• muskuloskeletal symptoms

maraviroc can lead to severe

hepato toxicity

there is a severe increase in toxicity with maraviroc when taking

• keto

• rito

• saquin

• ata

• dela

maraviroc cannot be taken if

• breast feeding

• usage of st. john wort

• coinfection HBV cardio events

if a patient has a coinfection of HBV they cannot also take CCR5s or they will expereicne

cardiac events

CCR5s are used in

adults only

CCR5s are excreted in the

feces