myelinopathies

hexachlorophene binding tightly to

cell membranes resulting in loss of ion gradients across membranes

hexachlorophene uncoupling

mitochondrial oxidative phosphorylation

lead neuropathy

peripheral neuropathy

lead prominent result

segmental demyelination

lead clinical result

encephalopathy

reason for lead encephalopathy

associated with dilated capillaries lined with necrotic endothelial cells - brain edema develops after hemorrhage

synaptic vesicle down axons and binding

release sites on the pre-synaptic membrane via v-SNARE and t-SNARES

SNARE complex interaction

both NSF and SNAP to form a fusion complex