Sites of Action on Nephron

Carbonic anhydrase inhibitor

What is Acetazolamide?

Proximal convoluted tubule

Where is acetazolamide used?

collecting duct, desending limb, PCT (where H2O is reabsorbed)

Where are osmotic agents (mannitol) used?

Ascending limb

Where are loop agents like furosemide used?

distal convoluted tubules

Where are thiazides used?

collecting duct

Where are aldosterone antagonists used?

collecting duct

Where are ADH antagonists used?

collecting duct

Where are Na+ channel blockers used?

65%

How much Na+ is filtered in glomerulus?

Proximal convoluted tubule

Where in the nephron is the most Na+ reabsorbed?

25-30%

How much Na+ is reabsorbed in the ascending limb?

Ascending loop of henle

Where is the strongest/ most efficacious class of diuretics used?

Glomerular capillary to renal tubule

Where does glomerular filtration occur?

Peritubular capillary to lumen of renal tubule

Where does tubular secretion occur?

Renal tubule to peritubular capillary

Where does tubular reabsorption occur?

alpha-1, M-1, M-3

What are receptors for Gq?

alpha-2, M-2

What are receptors for Gi?

B1, B2, B3

What are receptors for Gs?