Virology Effects on Host Cell

CPE

cytopathic effect

What is a CPE?

any observable cellular characteristics that is present in virus-infected cells and which is absent in uninfected cells.

Cell Lysis

CPE, cytolytic infection. (Causes plaque formation on cultured cells. )

Inclusion body formation

Discrete areas in the host cell nucleus or cytoplasm containing viral proteins or particles CPE

Inclusion bodies from rabies virus

negri bodies (forms in neurons)

Syncytium formation

adjacent cells merge into a continuous mass CPE (RSV) (multinucleated cell)

Transformation of cells by oncogenic retrovirus

Transformed cells display

- loss of contact inhibition

- anchorage-independence

- loss of serum-dependence (DONT need serum)

Virus-induced apoptosis

Not necessarily helpful for the virus.

Virus-induced shut off of host cell transcription and or translation.

Suppress the expression of specific cellular genes