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what does O2 and CO2 bind to
O2= heme Co2=globin
what percentage of CO2 is transported
7%
what percentage of CO2 is diffused into RBC
93%
what percentage of the 93% is chemically combined with Hb
23%
why is venous blood blue
because of CO2 binding
what percentage of the 93% is voncerted to HCO-3
70%
law of mass action
every reaction in body is reversible and the direction depends on how much substrates are available
haldane effect
CO2 loaded on Hb, affinity Hb + O2 low (tissues)
O2 loaded on Hb, affinity Hb + CO2 (lungs)
bohr effect
H+ formed CO2, H+ binds to Hb, affinity Hb + Oz low (tissue)
Oz binds to Hb, affinity Hb + H low (lungs)
why do we breath
to maintain blood/plasma pH levels
why isn’t breathing like your heart breathing
not autorhythmic (skeletal muscles), controlled by motor neurons and central pattern generator
what do chemoreceptors pick up
ions and molecules
where is the central chemorecpetor
brain
where are the peripheral chemoreceptors
carotid and aorta (same a barorecpetors)
what is the only thing to cross BBB
gas CO2 and O2
where is H+ detected
centrally
where is CO2 and O2 detected
peripherally
in healthy people what gas controls breathing
CO2
people with lung disease what controls breathing
O2