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Where does it occur
eukaryotes: mitochondrial matrix
prokaryotes: cytosol
Characteristics of the krebs cycle
amphibolic (both catabolic and anabolic)
closed cycle
takes the 2 carbons from acetyl-coA and releases them as CO2
Net gain
2 CO2
1 ATP/GTP by SLP
3 NADH
1 FADH2
Isocitrate → Ketoglutarate
1 NAD+ → 1 NADH
CO2
Ketoglutarate → Succinyl-CoA
1 CO2
1 NAD+ → 1 NADH
Succinyl CoA → Succinate
1 ADP → 1 ATP
Succinate → Fumarate
1 FAD → 1 FADH2
Malate → Oxaloacetate
1 NAD+ →NADH