toto

what is the ending for mouse mAB

omab

what is ending for chimeric mAB

ximab

what is ending for humanized mAB

zumab

what is ending for human mAB

umab

what factor of a mAB makes it more likely to elicit anti-therapeutic immune response

the more component of a mAB that is non-human

adv of nanobodies as therapeutics compared to mammalian Ig

one protein binding domain = easier manu

more stable = more resistant to pH and chemistry changes

disadv of nanobodies as therapeutics compared to mammalian Ig

low bioavailability = need modifications for efficacy

small = hard to work with

purpose of Fc region

HUMAN fc regions illicit immune response for antibody dependent cytotoxicity and complement dependent cytotoxicity

this part of the mAB interacts with NK cell

which mAB can bind to two different proteins

bi specific mAB

what are the benefits of a fragmant as a therapeutic

better at distributing to dense and poorly vascularized tissues = tumors

what terms are for patient’s own cells

autologos, autogenic

what terms are for therapeutics from other people’s cells

allogenic, heterologous

what factors limit CAR T cell therapeutics

need a specific target

off-target effects =cytokine toxicity/storm

what type of gene therapy reduces expression of mutated gene

gene silencing

what type of gene therapy fixes the mutated gene

genome editing

what type of gene therapy adds in a good copy of the gene

ectopic expression

pros and cons of gene silencing

pro: gets rid of overactive gene, SAFE = no risk of of-target effects

con: temporary and requires continuous therapy

pros and cons of genome editing

pro: fixes any problem

con: can lead to off target mutations

pros and cons of ectopic expression

pro: long term and generally safe

con: use of viral vectors can be limiting for some populations

what are the types of viruses for gene therapy

HSV-1

lentivirus

adeno-associated

which viral vectors are episomal

HSV-1

adeno-associated (occasional integrating)

which viral vectors are integrating vectors

lentivirus

what is an episomal vector and pros?

virus does not integrate into host genome

pro: used short term, lower risk of mutations

what is a integrating vector and pros?

vector embeds into host genome

pro: good long term, risk of mutations (cancer)

what is the FDA approved oncolytic therapeutic

imlygic (talimogene laherparepvec)

imglytic is used for

melanoma

what type of vector is used for imglytic

HSV-1

what is target of imglytic

GM-CSF

what are the reasons for a placebo in vaccine trial

if there is an established treatment = unethical to use inactive placebo

what vaccine type needs target antigens

viral vector

mRNA

protein subunit

which vaccines do not need specitific target antigens

whole inactivated

live attenuated