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Gregor Mendel
Genes exist
Morgan
Genes are on chromosomes
Miescher
Found nucleic acid
Kossel
Finds nitrogenous bases
Levine
DNA vs RNA
Linkage of nucleotide (sugar, phosphate base)
Tetra nucleotide hypothesis
Griffith
Transformation
Heat kill IIIs IIR
Avery, McCarthy, MacCleod
Purify ‘transforming principle’ (looks like DNA)
Enzymes (RNase destroys RNA, DNase, proteinase)
Only DNase stops transformation
Chargraff
Refute tertanucleotide
Each species has a unique % of AGCT
A=T, G=C
Hershey and Chase
33p, 35s
DNA vs protein to track bacteriophage reproduction
Franklin, Watson and Crick