CHOLINERGIC AND ADRENERGIC TRANSMISSION DRUGS

PHARMACOLOGICAL ALTERATION OF SYMPATHETIC NORADRENERGIC FUNCTION and MODIFYING CHOLINERGIC NEUROTRANSMISSION

No Clinical Example

A sympathetic noradrenergic drug that causes precursor transport blockade.

metyrosine

A sympathetic noradrenergic drug that inhibits tyrosine hydroxylase… and is used to treat pheochromocytoma

carbidopa

A sympathetic noradrenergic drug that inhibits Dopa decarboxylase

disulfiram

A sympathetic noradrenergic drug that inhibits Dopamine-β-hydroxylase

pargyline, tranylcypromine, selegiline

A sympathetic noradrenergic drug that inhibits Monoamine oxidase

reserpine

A sympathetic noradrenergic drug that inhibits storage… and prevents NE storage

guanethidine, guanadrel

A sympathetic noradrenergic drug that inhibits release… and causes initial release of NE, leading to depletion of catecholamine

bretylium

A sympathetic noradrenergic drug that inhibits release… and blocks NE release

alpha- and beta-agonists and antagonists

A sympathetic noradrenergic drug that inhibits receptors

cocaine, tricyclic antidepressants

A sympathetic noradrenergic drug that causes Norepinephrine transporter (Uptake I) blockade

entacapone

A sympathetic noradrenergic drug that inhibits Catechol-O-methyltransferase (COMT)

glucocorticoids

A sympathetic noradrenergic drug that inhibits Uptake II

hemicholinium

A modifying cholinergic neurotransmission drug that causes precursor transport blockade (CHT)

no clinical example

A modifying cholinergic neurotransmission drug that inhibits Choline acetyltransferase (ChAT)

black widow spider venom (latrotoxin)

A modifying cholinergic neurotransmission drug that promote transmitter release (choline)

botulinum toxin (Botox)

A modifying cholinergic neurotransmission drug that prevent transmitter release (VAMPs)

vesamicol

A modifying cholinergic neurotransmission drug that inhibits storage (VAT)… and prevents ACh storage

physostigmine, neostigmine

A modifying cholinergic neurotransmission drug that inhibits Cholinesterase (AChE)

agonists and antagonists

A modifying cholinergic neurotransmission drug that inhibits receptors