PATHOLOGY EXAM 3

follow up

management for mild dysplasia

severe dysplasia

atypical morphology involving ENTIRE thickness of epithelium

pleomorphism

abnormal shape and size of cells

excisional biopsy

complete surgical removal

fibroma, mucocele, lipoma, or papilloma

lesions that would be biopsied with EXCISIONAL biopsy

large, leukoplakia, erythroplakia, ulcer, SCC, tumor, lichen planus

lesions that would be biopsied with INCISIONAL biopsy

leukoplakia

clinical term used to describe white premalignant lesion

gingiva

common site for proliferative verrucous leukoplakia

floor of mouth, lateral/ventral tongue, lower lip, soft palate

high risk sites for premalignant lesions and cancer

premalignant

what is the concern with this lesion

proliferative verrucous leukoplakia

lesion with highest risk of malignant tranformation

incisional biopsy

what is the management of this lesion

cellular atypia

histological hallmark of epithelial dysplasia

actinic cheilosis (farmers/sailors lip)

what is this lesion

oral submucous fibrosis

due to beta nut chewing

cancer

what do you want to rule out

red and white mixed lesion

clinical feature that raises the most concern for dysplasia or. carcinoma

chewing tobacco

what is the cause of this lesion

basal cell carcinoma

typically presents with central depression and rolled borders

smokeless tabacco

habit strongly associated with verrucous carcinoma

basal cell carcinoma

most common type of skin cancer

squamous cell carcinoma

most common type of ORAL cancer

floor of mouth

highest risk site for oral cancer

lip arises from actinic cheilitis

what distinguishes lip from oral SCC?

oral

type of SCC that has worst prognosis

any M, T4, or N1

stage with worst prognosis

T1 N0 M0

stage with BEST prognosis

through lymph nodes

how is metastatic disease spread

metastatic disease

presents with painless, enlarged, stiff, and immobile lymph nodes.

basal cell carcinoma

GORLIN SYNDROME is associated with

smoking cigarettes

highest risk factor for oral squamous cell carcinoma

lung

most common SITE for OSCC to metastasize

HPV+ non smoker

type of OSCC with best prognosis

HPV- smoker

type of OSCC with worst prognosis

incisional biopsy

what is the appropriate management

tumor size

what does T in TNM stand for?

verrucous carcinoma

what is the diagnosis

lymphatic spread

main route of metastasis for OSCC

incisional biopsy

what is the best management of this lesion

dorsum of tongue

which location is LEAST likely to be affected by OSCC

basal cell carcinoma

what is the most likely diagnosis

smokeless tobacco

verrucous carcinoma is most commonly associated with?

scar-like texture

characteristic of morpheaform basal cell carcinoma

HPV

virus linked to OSCC

sentinel lymph node

FIRST node to receive metastatic cells from primary tumor

basal cell carcinoma

rodent ulcer is known as

snuff dippers/ackerman’s tumor

other names for verrucous carcinoma

HPV 16

type of HPV linked to OSCC

stage 4

stage of OSCC that has spread to lungs

surgical excision

treatment for squamous papilloma

HPV 2

cause of verruca vulgaris

soft palate

most common location for oral squamous papilloma

condyloma

multiple bulbous papillary lesions

16 and 18

high risk HPV types

shingles

presents with unilateral, painful, vesicular lesions distributed along skin of trigeminal nerve

measles

childhood disease presents with KOPLIK SPOTS

condyloma acuminatum

SEXUALLY transmitted lesion that may RECUR after treatment

on keratinized mucosa only

distinguishing feature of recurrent intraoral herpes

hairy leukoplakia

oral lesion associated with EPSTEIN BARR in immunocompromised patients

primary herpetic gingivostomatitis

8 year old patient with fever, fatigue, and intra oral lesions. diagnosis?

HPV 2, 6, or 11

viruses that could causes this lesion

HSV 1

cause of this lesion

deafness

most common complication of congenital rubella syndrome

surgical excision

management?

burkitt lymphoma

associated cancer of EPSTEIN BARR virus

koplik spots

what are these spots, caused by PARAMYXOVIRUS (measles)

lymphadenopathy, enlarged tonsils, prodromal signs

characteristic features of infectious mononucleosis

HIV/AIDS

what disease are these lesion associated with?

kaposi sarcoma

diagnosis

HHV-8

cause of these lesions

hairy leukoplakia, nasopharyngeal carcinoma, infectious mono

diseases caused by EPSTEIN BARR virus

primary herpetic gingivostomatitis (primary herpes)

diagnosis?

rheumatic fever

possible complication of untreated strep throat

red, prominent fungiform papillae

cause of strawberry appearance of tongue in scarlet fever

weight loss, night sweats, fever, persistent cough

symptoms of tuberculosis

scrofula

form of tuberculosis with CERVICAL lymph node involvement due to CONTAMINATED MILK

primary

stage of SYPHILIS that presents with CHANCRE

decayed tooth

most common predisposing factor for ACTINOMYCOSIS

rule out malignancy

reason for BIOPSY in OSTEOMYELITIS

lymph nodes

CAT SCRATCH disease spreads to?

opportunistic infection

non-pathogenic organisms causing disease in compromised hosts

angular cheilitis

form of CANDIDIASIS associated with NUTRITIONAL DEFICIENCY

acute atrophic candidiasis

CANDIDIASIS after ANTIBIOTIC therapy

median rhomboid glossitis

candidiasis variant with ERYTHEMA and PAPILLA loss on TONGUES MIDLINE

clinical features and mucosal smear

primary DIAGNOSTIC METHODS for CANDIDIASIS

fluconazole and ketoconazole

systemic antifungals

pseudomembranous candidiasis

patient complains of metallic taste and burning sensation, diagnosis?

nystatin oral suspension

management?

predisposing factors

in addition to antifungal therapy, what should be addressed for LONG TERM CANDIDIASIS CONTROL

primary involvement of lungs in immunocompromised

common feature of DEEP FUNGAL infections

diabetes

typical risk factor for MUCORMYCOSIS

congenital syphilis

condition associated with these abnormal teeth

ill defined asymmetric radiolucency

typical radiographic finding in CHRONIC OSTEOMYELITIS

denture stomatitis

diagnosis

antifungal therapy

management?

white plaque, can be wiped off

key characteristic of PSEUDOMEMBRANOUS CANDIDIASIS

wickham striae

clinical feature of RETICULAR lichen planus

erythema and bleeding

sign of EROSIVE lichen planus

clobetasol

treatment for lichen planus

moveable mucosa (ex: buccal)

location of apthous ulcer