Diseases Associated w/ Nucleotide Metabolism
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8 Terms
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SCID
severe combined immunodeficiency syndrome, especially
adenosine deaminase deficiency can be treated with gene
therapy/bone marrow transplant
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Lesch-Nyhan Syndrome
fatal defect in purine salvage
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Antibiotics
Sulfanilamide & Trimethoprim inhibit tetrahydrofolate (THF) pathways
in bacteria
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Gout
Buildup of uric acid in the blood can be reduced by allopurinol
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Azaserine
Gln analog that inhibits purine biosynthesis
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Fluorouracil
Inhibits thymidylate synthase
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Methotrexate
Inhibits dihydrofolate reductase (M)
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Aminopterin
Inhibits dihydrofolate reductase (A)
Note 
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