Complement System Disease

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9 Terms

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Complement System

Very efficient weapon against infection by

amplifying phagocytosis

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C3a and C5a

Receptors for these complements have been found in coronary plaques

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C2 deficiency

Most common Complement Deficiency

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Atherosclerosis

Recurrent Streptococcal and Staphylococcal infections

Lupus like syndrome

C2 deficiency will lead to these diseases

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MBL

important during the interval between the loss of passively acquired maternal antibodies and the ability of infants to produce their own antibody

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Pneumonia

Sepsis

Meningococcal disease in infants

Lack of MBL will lead to these diseases

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C3 deficiency

most severe type

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Large scale gram negative infection
Tissue Necrosis
Hemolysis

Complement can be harmful if this factors is present

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Hereditary deficiency of Complement

Increased susceptibility to infection. Delayed clearance of immune complexes.