Therapies for Hyperkalemia and their MOA

MOA of 10% Calcium gluconate to treat hyperkalemia

Increases threshold voltage but will not lower serum potassium

NaHCO3

Increases extracellular pH and promotes intracellular shift of potassium in exchange for H+ ions

Insulin/Dextrose

intracellular shift of potassium through activation of Na+-K+-ATPase

Dextrose 50%

intracellular shift of potassium through activation of Na+-K+-ATPase

Insulin

intracellular shift of potassium through activation of Na+-K+-ATPase

Terbutaline

Stimulates Na+/K+-ATPase to cause translocation of potassium into the cell