spectrum of activity

what are the susceptible gram positives

MSSA

streptococcus spp

enterococcus faecalis

what are the resistant gram positives

MRSA

VRE E. faecalis

VRE E. faecium

what are the susceptible gram negatives

pseudomonas aeruginosa

enterobacterales (E. coli)

acinetobacter baumannii

what are the resistant gram negatives

CRE/KPC+ E.coli

ESBL+ E.coli

what are the anaerobes

gram negative (bacteroidies fragilis)

gram positive (peptoniphilus spp)

what are the atypical organisms

Chlamydia spp.
Legionella spp.
Mycoplasma pneumoniae
Mycobacterium tuberculosis

penicillin G

Streptococcus spp

Enterococcus faecalis

Gram positive anaerobes

penicillin VK

Streptococcus spp

Gram positive anaerobes

Naficillin

MSSA

Streptococcus spp

Oxacillin

MSSA

Streptococcus spp

Dicloxacillin

MSSA

Streptococcus spp

amoxicillin (Amoxil)

streptococcus spp

enterococcus faecalis

gram positive anaerobes

ampicillin

streptococcus spp

enterococcus faecalis

gram positive anaerobes

amoxicillin/clavulanate (Augmentin)

MSSA

streptococcus spp

enterococcus faecalis

enterobacterales

gram negative anaerobes

gram positive anaerobes

ampicillin/sulbactam

MSSA

streptococcus spp

enterococcus faecalis

enterobacterales

gram negative anaerobes

gram positive anaerobes

piperacillin/tazobactam (Zosyn)

MSSA

streptococcus spp

enterococcus faecalis

pseud0monas aeruginosa

enterobacterales

gram negative anaerobes

gram positive anaerobes

sulbactam/durlobactam

acinetobacter baumannii

cefazolin

MSSA

streptococcus spp

enterobacterales

gram positive anaerobes

cephalexin (Keflex)

MSSA

streptococcus spp

gram positive anaerobes

cefadroxil

MSSA

streptococcus spp

gram positive anaerobes

cefuroxime

MSSA

streptococcus spp

enterobacterales

gram positive anaerobes

cefprozil

MSSA

streptococcus spp

enterobacterales

gram positive anaerobes

cefaclor

MSSA

streptococcus spp

gram positive anaerobes

cefoxitin

MSSA

streptococcus spp

enterobacterales

ESBL + E.coli

gram positive anaerobes

cefotetan

MSSA

streptococcus spp

enterobacterales

ESBL + E.coli

gram positive anaerobes

ceftriaxone (Rocephin)

MSSA

streptococcus spp

enterobacterales

gram positive anaerobes

cefotaxime

MSSA

streptococcus spp

enterobacterales

gram positive anaerobes

ceftazidime (+/- avibactam)

streptococcus spp

pseudomonas aeruginosa

enterobacterales

CRE/KPC + E. coli (combo)

ESBL + E. coli (combo)

gram positive anaerobes

cefdinir

MSSA

streptococcus spp

enterobacterales

cefpodoxime

MSSA

streptococcus spp

enterobacterales

gram positive anaerobes

cefixime

streptococcus spp

enterobacterales

gram positive anaerobes

cefepime (Maxipime) (+/- enmetazobactam)

MSSA

streptococcus spp

pseudomonas aeruginosa

enetobacterales

ESBL + E.coli (combo)

gram positive anaerobes

ceftaroline

MSSA

streptococcus spp

MRSA

enterobacterales

gram positive anaerobes

cefiderocol

pseudomonas aeuginosa

enterobacterales

acinetobacter baumannii

CRE/KPC + E.coli

ESBL + E. coli

ceftolozane/tazobactam

MSSA

streptococcus spp

pseudomonas aeuginosa

enterobacterales

ESBL + E. coli

gram negative anaerobes

gram positive anaerobes

ceftobiprole

MSSA

streptococcus spp

MRSA

enterobacterales

gram positive anaerobes

imipenem/cilastatin

MSSA

streptococcus spp

enterococcus faecalis

pseudomonas aeruginosa

enterobacterales

ESBL + E. coli

gram negative anaerobes

gram positive anaerobes

meropenem

MSSA

streptococcus spp

pseudomonas aeruginosa

enterobacterales

ESBL + E. coli

gram negative anaerobes

gram positive anaerobes

doripenem

MSSA

streptococcus spp

pseudomonas aeruginosa

enterobacterales

ESBL + E. coli

gram negative anaerobes

gram positive anaerobes

ertapenem

MSSA

streptococcus spp

enterobacterales

ESBL + E. coli

gram negative anaerobes

gram positive anaerobes

imipenem/cilastatin/relebactam

MSSA

streptococcus spp

enterococcus faecalis

pseudomonas aeruginosa

enterobacterales

CRE/KPC + E.coli

ESBL + E. coli

gram negative anaerobes

gram positive anaerobes

meropenem/varobactam

MSSA

streptococcus spp

pseudomonas aeruginosa

enterobacterales

CRE/KPC + E.coli

ESBL + E. coli

gram negative anaerobes

gram positive anaerobes

aztreonam

pseudomonas aeruginosa

enterobacterales

axteonam+avibactam

pseudomonas aeruginosa

enterobacterales

CRE/KPC + E.coli

ESBL + E. coli