Cell Cycle CCB

interphase is the

preparation for mitosis (G1,G2,S1,S2)

prophase is when the

chromosmes condencse, micrsotubules form, and nuclues disipates

metaphase occurs when

homologous chromosomes align and kinetochroes align

anaphase is when

everything gets pulled apart

telophase is when

nucleur envelope forms, nucleus forms, chromosomes decondense, ultimately clevage occurs

metaphase -anaphase trnasition is influenced by

chromosome attachments to spindle

the restriction point following G1 is influenced by

growth factors, nutrients, cell size, dna damage

the G2-M transition is influenced by

cell size, DNA damage, DNA replication

damaged tissue may remain in the

G2-M transition

Cells that do not want to replicate; such as neurons may remain in the

G0 phase

G1 can be restricted by a lack of

nutrients or growth factor

MPF

mitotic promoting factor

mitotic cyclin and MPF act as

triggers for turning on mitosis

when mitotic CDK and mitotic cyclin first bind they form a

inactive complex

two inhibitory phosphate groups are attached to the CDL molecule by enzymes called

inhibiting kinases

An activating phosphate group is added by an

activating kinase

as long as CDK remains inactive as long as the

inhibitory phosphate groups are present

a phosphatase removes the inhibiting phosphates thereby

activating the mitotic CDK-cyclin complex

actice mitotic CDK-cyclin stimulates

1. nuclear envelope breakdown

2. chromosome condensation

3. mitotic spindle formation

4. targeted protein degradation

What key jobs does anaphase promoting complex do?

1. pull complex apart and degrade mitotic cyclin

2. degrade proteins that hold the cell together