Plasma Proteins

Plasma Proteins

• the most frequently analyzed of all the proteins

Albumin and Globulin

the major plasma proteins are divided into two groups:

Pre albumin

Binds thyroxine; transport vitamin A

Albumin

• oncotic pressure; amino acid reservoir; carries small molecules

Pre albumin

• sensitive marker for poor nutrition status

Albumin

Protein present is highest concentration in plasm

Albumin

It is a sensitive and highly prognotic marker of cystic fibrosis

• a1-antitrypsin

• a1-fetoprotein

• a1-acid glycoprotein

• a1-lipoprotein

• a1-antichymotrypsin

• inter-a1 trypsin inhibitor

• Gc-globulin

A1-globulins:

• Haptoglobin

• Ceruloplasmin

• a2-macroglobulin

a2-globulin:

• Transferrin

• Complement

• Fibrinogen

• CRP

• hemopexin

Beta globulin:

• IgG, A,M,E,D

• Fibronectin

gamma globulin:

Hypoproteinemia

• total protein level less than reference interval

• Occurs in any condition where a negative nitrogen balance exists

Hyperproteinemia

• an increse in total plasma proteins

• Occurs in dehydration, when concentration of proteins is elevated due to decreased volume of solvent water