Study Tip Gal

PD refers to

drug on body

PK refers to

body on drug

active metabolite of capecitabine

fluorouracil

active metabolite of clopidogrel

active metabolite

active metabolite of codeine

morphine

active metabolite of colistimethate

colistin

active metabolite of cortisone

cortisol

active metabolite of famciclovir

peninciclovir

active metabolite of fosphenytoin

phenytoin

active metabolite of isavuconazonium sulfate

isavuconazole

active metabolite of levadopa

dopamine

active metabolite of lisdexamphetamine

dextroamphetamine

active metabolite of prednisone

prednisolone

active metabolite of tramadol

active metabolite

active metabolite of valacyclovir

acyclovir

active metabolite of valganciclovir

ganciclovir

CYP inhibitors + effect on substates and produgs

HINT
G ❤ PACMAN



Grapefruit
Protease inhibitors
Azole
Cyclosporine, Cobisistat
Macrolides (NOT azithromycin)
Amiodarone
Non-DHP CCBs
Substrate: decrease metabolism, increase serum levels and toxicity
prodrug: decrease conversion to active metabolite, decrease clinical effects

CYP inducers + effect on substates and produgs

HINT
PS PORCS



Phenytoin
Smoking
Phenobarbital
Oxcarbazepine
Rifampin
Carbamazepine
St Johns Wort
Substrate: increase metabolism, decrease serum levels and toxicity
prodrug: increase conversion to active metabolite, increase clinical effects

guideline names: anticoag

CHEST

guideline names: CV diseases

AAC/AHA

guideline names: diabetes

AACE
ADA

guideline names: infectious disease

IDSA
Clinicalinfo.hiv.gov
CDC

guideline names: oncology

ASCD
NCCN

guideline names: pediatric

AAP

guideline names: pregnancy/womens health

ACOG

guideline names: psychiatric

APA
DSM-5

guideline names: Asthma

GINA

guideline names: COPD

GOLD

guideline names: renal

KDIGO

guideline names: vaccines

ACIP
CDC

orange book

therapeutic equivalence

pink book

epidemiology and vaccine
regulatory, legal, business news

Puruple book

biosimilars

red book

drug pricing
ID vaccines for Peds

yellow book

international travel

green book

approved animal drugs

BID batch frequency

diclofenac (flector only)

daily w/ instructions patch frequency

lidocaine: 1-3 pathcs 12 on 12 off
nitroglycerin: 12-14 on 10-12 off

q72h patch

fentanyl
scopolamine

twice weekly patch

estradiol (vivelle)
oxybutinin

weekly patch frequeny

estradiol (climoara)
ethinyl estradiol/norelgestromin
ethinyl estradiol/levonorgestrel
clonidine
donepezil
buprenorphine

1 tsp

5 mL

1 tbsp

15 mL

1 fl oz

30 mL

1 cup

8 oz
240 mL

1 pint

16 oz
480 mL

1 quart

2 pints
960 mL

1 gallon

4 quart
3840 mL

1 kg

2.2 lbs

1 oz

28.4 g

1 lb

454 g

1 gr

65 mg

1 in

2.54 cm

1 m

100 cm

mEq=

mg*valence
MW

carb kcals

3 kcals/g
dextrose: 3.4 kcal/g

fat kcals

9 kcal/g
10% ILE 1.1 kcal/mL
20% ILE 2 kcal/mL
30% ILE 3 kcal/mL

protein kcal

4 kcal/g

what weight to use if underweight, normal, overweight, obese for drug dosing (+exceptions)

underweight: TBW
normal: TBW
overweight: TBW
obese: TBW
Acyclovir, amiophylline/theophylline, levothroxine: TBW > IBW → IBW
Aminoglycoside: overweight TBW or IBW, obese: TBW > 120% IBW -→ AdjBW

Weight to use for CrCl

TBW < IBW → TBW
TBW > IBW and BMI < 25 → IBW
TBW > IBW and BMI > 25 → AdjBW

alkolosis vs acidosis - low pH

acidosis

alkolosis vs acidosis - high pH

alkalosis

alkolosis vs acidosis - low CO2

alkalosis

alkolosis vs acidosis - high CO2

acidosis

alkolosis vs acidosis - low bicarb

acidosis

alkolosis vs acidosis - high bicarb

alkalosis

pH high CO2 low

respiratory alkalosis

pH low CO2 high

respiratory acidosis

pH high HCO3 high

metabolic acidosis

pH low HCO3 low

metabolic acidosis

comparing difference data CI crosses 0

NOT statisically significant

comparing difference data CI does not cross 0

statisically significant

comparing ratio data - CI crosses 1

NOT statisically significant

comparing ratio data - CI does not cross 1

statistically significant

how to round NNT and NNH

NNT: round up
NNH: round down

avoid alcohol as an excipient in what patient population

children

avoid aspartameas an excipient in what patient population

phenylketonuria

avoid gelatin as an excipient in what patient population

vegans

avoid glutenas an excipient in what patient population

celiac disease

avoid lactoseas an excipient in what patient population

allergy/intolerance

avoid preservatives as an excipient in what patient population

neonates

avoid sugar alcohols as an excipient in what patient population

IBS

avoid sucrose as an excipient in what patient population

diabetes

avoid xylitol as an excipient in what patient population

avoid alcohol as an excipient in what patient population

BUD for aqueous nonpreserved

14 days refrigerated

BUD for aqueous preserved

35 days

BUD for nonaqueous oral liquid

90 days

BUD for nonaqueous other

180 days