Retroviral Integration

Bio 300 Discussion

1. Virus attaches to membrane

2. Reverse transcriptase synthesizes first strand of DNA

3. Reverse Transcriptase degrades RNA

4. Reverse Transcriptase synthesizes second strand of DNA

5. Viral DNA is integrated into host DNA

6. Viral DNA is transcribed

7. Viral RNA is exported

8. Viral RNA is translated

9. Viral RNA and Proteins are packed into new virus

Retrotransposons are not able to escape from the cell

RNA dependent DNA polymerase activity (Step 2)

Ribonuclease H activity

DNA dependent DNA polymerase activity