Neoplasia Chemotherapy Drug Classes

Antimetabolites (S phase)

Antifolate: Methotrexate

Nucleic Acid Analog: 5-FU, Capecitabine, Gemcitabine

Topoisomerase II inhibitor (G¹-S phase)

Etoposide

Topoisomerase I inhibitor (G²-M phase)

Irinotecan

Taxanes (M phase)

Paclitaxel

Vinca alkaloids (M phase)

Vinblastine

Vincristine

Antimicrotubule inhibitor (M phase)

Ixabepilone

(newer for metastatic breast cancer)

Anti-tumor antibiotics CCS (G²-M phase)

Bleomycin

Platinum analogs

Cisplatin

Nitrosoureas

Carmustine

Streptozocin

Other Alkylating agents

also called Bis(chloroethyl)amines (cross-linking)

Cyclophospamide

Mechlorethamine

Methylating agents

Procarbazine

(Hodgkin’s lymphoma)

Anti-tumor antibiotics CCNS

Dactinomycin

Mitomycin

Anthracyclines

Daunorubicin

Doxorubicin

Other CCNS agents

Hydroxyurea

26s protease inhibitors

Bortezomib

Tyrosine Kinase inhibitors

Imatinib

EGFR/HER inhibitors

Trastuzumab

VEGF inhibitors

Bevacicumab

Sorafenib

Aflibercept

Given with Cyclophosphamide

MESNA

Given with Antifolates

Leucovorin

Given with Anthracyclines

Dexrazoxane