HSCs interact with stromal cells
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What cell surface molecule do HSCs express to interact with stromal cells?
c-Kit
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What signaling molecule on stromal cells binds to c-Kit on HSCs?
Stem cell factor (SCF)
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What are the two main roles of c-Kit and SCF interaction in HSCs?
1) Maintains contact between HSCs and stromal cells.
2) Drives differentiation into multipotent progenitor cells.
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