Nucleotide Metabolism
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5 Terms
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What is the rate-limiting enzyme of purine synthesis?
Glutamine-PRPP amidotransferase
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What inhibits purine synthesis?
AMP, GMP, IMP (feedback inhibition)
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What enzyme forms dTMP from dUMP?
Thymidylate synthase (requires folate)
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What drug inhibits dihydrofolate reductase?
Methotrexate (humans), Trimethoprim (bacteria)
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What is the key enzyme in pyrimidine synthesis?
Carbamoyl phosphate synthetase II (uses glutamine, occurs in cytosol)
Note 
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