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pathogen associated molecular patterns (PAMPs)

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23 Terms

1

pathogen associated molecular patterns (PAMPs)

molecules expressed by pathogens not found on mammalian ceells

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2

viral RNA (ssRNA and dsRNA), bacterial LPS, microbial carbohydrates

examples of PAMPs

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3

pattern recognition receptors (PRR)

specific rceptos on innatee immune cell that recognize PAMPs

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4

Damage associated molecular patterns (DAMP)

mammilian cell components expressed upon cellular damage

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5

heat shock proteins

example of DAMP

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6

alternate and lectin

what complement systems are activated in response to S. aureus

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7

opsonization and cytolysis, recruitment of inflammatory cells, elimination of invaders

key functions of complement system

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8

cytokines (TNF-a, IL-1, IL-6)

Activate endothelial cells to express selectins and synthesize chemokines

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9

cytokines (TNF-a, IL-1, IL-6)

activate resident immune cells and stimulate phagocytosis

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10

cytokines (TNF-a, IL1, IL-6)

causes induction of fever through prostaglandin synthesis

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11

IL-8 (CXCL8)

primary rercruiterr of neutrophils to sites of acute inflammation

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12

MCP-1 (CCL2)

primary recruiterr of monocytes to sites of inflammation

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13

prostaglandins

causes vascular permeability, fever, and hyperalgesia

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14

prostaglandins and leukotrienes

arachidonic metabolites active in innate immunity

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15

leukotrienes

arachidonic acid metabolite associated with allergic reaction and inflammation

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16

macrophages, mast cells, dendritic cells

which resident cells of innate immunity are the first to respond

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17

macrophage

resident cell of innate immunity whos role is phagocytosis, ROS and NO, ANgiogenesis and fibrosis

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18

mast cells

resident cell of innate immunity whos role is degranulation to release cytokines and amines

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19

dendritic cells

resident cell of innate immunity whose role is to process and present antigens to T cells

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20

neutrophils

first line of defense against invading pathogens

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21

macrophage phagocytose orr become pus if in large numbers

what happens to dead neutrophils

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22

increased vasodilation and vascular permeability

what causes swelling, redness and warmth at site of injury

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23

TNF-1, IL-1, and IL-6 changin therrmal set pot and triggering acute phase response

what causes fever with shaking chills

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