Theories on Aging- Epigenetics
Studied by 1 person
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt Play1/5
Earn XP
Description and Tags
lecture 6, midterm 2
Name | Mastery | Learn | Test | Matching | Spaced | Call with Kai |
|---|
No analytics yet
Send a link to your students to track their progress
6 Terms
epigenetics
way of modifying DNA without changing the sequence.
how much or what is expressed
regulates gene expression
Affect chromatin structure and therefore DNA accessibility
epigenetic modifications
DNA methylation (DNAm) – methyl groups added
histone modification
chromatin remodeling
global DNAm decreases with age
however specific regions of DNA can see more DNAm
epigenetic drift
areas with lots of DNAm → reduction in DNAm; and vice versa
factors and effects
HIIT: can immediately decreasem DNAm but with 6 months of training: increased DNAm in fat cells.
Environment (diet, activity, nutrition) can affect epigenetics
epigenetic age
Amount of modification to DNA: epigenetic clock.
A way of measuring your biological age.
DNA methylation (DNAm) and epigenetic age:
• Tissue specific
• Tissue independent
• Can predict chronological age with an average error of ~2 years (range 1-3 yrs)
• Epigenetic age acceleration (DNAm acceleration): when your DNA is older than you are
• Can predict risk of chronic diseases
Note 
Flashcards (129)