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epidermis
outermost layer of skin
keratinocytes arranged into layers called strata

difference between thin and think skin
thin skin epidermis has 4 strata layers
thick skin epidermis has 5 strata layers (palms and soles)
strata (layers) of the epidermis
stratum corneum
stratum lucidum (THICK SKIN ONLY)
stratum granulosum
stratum spinosum
stratum basale

stratum corneum
outermost layer
strengthened to provide a protective barrier by the presence of keratohyalin
protein structure within keratinocytes

stratum lucidum
found only on the palms of the hands and soles of the feet
densely packed dead cells filled with keratin

keratin
structural protein that gives skin, hair, and nails its hard, water-resistant properties
stratum granulosum
keratinocytes that have stopped dividing and started producing keratin

keratohyalin
granulated protein which accumulate as lamellar granules within cells
waterproof

stratum spinosum
layers of keratinocytes bound together by desmosomes
dendritic cells defend against microorganisms and superficial skin cancers

stratum basale
deepest layer of epidermis
highest rate of reproduction of new skin cells
melanocytes and merkel cells
production of melanin and touch sensation

dermis
composed mainly of connective tissue
contains blood vessels, hair follicles, sweat glands
supports the epidermis

layers of dermis
papillary layer
reticular layer
hypodermis

papillary layer
dermal papillae in this region (ridges of skin that make fingertips)
loose areolar connective tissue
contains capillaries, lymphatic vessels, and sensory neurons

reticular layer
dense irregular connective tissue
collagen fibers
contains blood vessels, nerve fibers, accessory organs (hair follicles, sweat glands)

elastin fibers
increase elasticity of the dermis
cleavage lines
orientation of collagen fibers in dermis
generally parallel to underlying muscle fibers
where surgeons try to cut along to minimize scaring
hypodermis
connective tissue connecting skin (dermis) to underlying bone and muscle
provides insulation and padding
dominated by adipose tissue
