Unit 2 Ketone Bodies and related

RBCs can't use ketone bodies because

They don't have a mitochondria and instead use glycolysis

Where are ketone bodies formed

Mitochondria

How does Acetoacetate become Beta Hydroxybutyrate

Acetoacetate gets reduced by NADH (Acetoacetate can become acetone by a spontaneous reaction)

Ketone bodies form because of

Lack of OAA (meaning acetyl coa turns into ketone bodies instead of being used in TCA)

HMG coa synthase during ketogenesis found in

Mitochondria (HMG coa synthase during cholesterol synthesis found in cytosol)

β-hydroxybutyrate production is favored when

There is an NADH abundance

The two abundant ketone bodies are

Acetoacetate and β-hydroxybutyrate (third is acetone which is less acidic than the two)