MLB4810 Blood Bank - ABO and Other Ab Groups

ABO locus found on Chromosome

9

ABO Ab are

Naturally occurring

NOT present at birth

Anti-A,B is an (type of Ig)

IgG

H substance is present in greatests quantity to lowest quantity:

Group O > A₂ > B > A₂B > A₁ >A₁B

Anti-H lectin U.europaeus reacts with all RBCs except

Bombay

Galactose on the surface of the RBC is converted to the sugar ________

L-fucose

Galactose is converted to L-fucose by the H gene, starting production of

a-2-L fucosyltransferase

L-fucose is the dominant sugar responsible for

Blood group specificity

In Group ____ blood, the H substance is unmodified

O

The _____ gene starts production of a-3-N acetylgalactosaminyltransferase

A

The _____ gene starts production of a-3-D galactosyltransferase

B

a-3-N acetylgalactosaminyltransferase transfers ____ sugar to the H substance

Acetyl-D-galactosamine

a-3-D galactoyltransferase transfers ___ to the H substance

D-galactose