Pharmacodynamics Lecture #1

Drug

Exogenous chemical agent used to modify physiology

Pharmacology

study of the uses of chemical agents for therapeutic purposes

Toxicology

Adverse effects of a drug

Receptor

site of action

Agonist

Drug that mimics a biological effect

Antagonist

Drug that inhibits a biological effect

Pharmacodynamics

What the drug does to the body (therapeutic and toxic)

Pharmacokinetics

What the body does to the drug (ADME)

5 Receptor Types Pneumonic

I Got Rick Ranch Inside

“I” receptor

Ion Channel

“Got” Receptor

G-Protein Coupled

“Rick” Receptor

Receptor with Intrinsic Enzyme

“Ranch” Receptor

Receptor with associated enzyme

“Inside” Receptor

Intracellular receptor

Half of all drugs target what receptor?

G protein coupled

Activated form of G Protein

GTP

Drug Binding Forces Weak —> Strong

Hydrophobic, Hydrogen, Ionic, Covalent

Irreversible Bond Type

Covalent

Most Common Drug binding

Ionic

EC50 Measures what?

Potency

Emax measures what

Efficacy / effect