Pharmacodynamics Lecture #1
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26 Terms
Drug
Exogenous chemical agent used to modify physiology
Pharmacology
study of the uses of chemical agents for therapeutic purposes
Toxicology
Adverse effects of a drug
Receptor
site of action
Agonist
Drug that mimics a biological effect
Antagonist
Drug that inhibits a biological effect
Pharmacodynamics
What the drug does to the body (therapeutic and toxic)
Pharmacokinetics
What the body does to the drug (ADME)
5 Receptor Types Pneumonic
I Got Rick Ranch Inside
“I” receptor
Ion Channel
“Got” Receptor
G-Protein Coupled
“Rick” Receptor
Receptor with Intrinsic Enzyme
“Ranch” Receptor
Receptor with associated enzyme
“Inside” Receptor
Intracellular receptor
Half of all drugs target what receptor?
G protein coupled
Activated form of G Protein
GTP
Drug Binding Forces Weak —> Strong
Hydrophobic, Hydrogen, Ionic, Covalent
Irreversible Bond Type
Covalent
Most Common Drug binding
Ionic
EC50 Measures what?
Potency
Emax measures what
Efficacy / effect
Note 
Flashcards (97)