DNA repair mechanisms in somatic hypermutation
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What happens to cytosine in somatic hypermutation?
It is converted to uracil by activation-induced cytidine deaminase (AID).
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What are the three possible DNA repair mechanisms in somatic hypermutation?
DNA replication
Base excision repair
Mismatch repair
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How do DNA repair mechanisms contribute to somatic hypermutation?
They can introduce mutations at the changed base pair, increasing immunoglobulin diversity.
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