Genetics Ch. 13 Eukaryotic Chromosome Review

1. The components of a chromosome include one long DNA molecule and

Proteins

2. By weight, chromatin consists roughly of

A. 1/3 DNA, 1/3 histones, and 1/3 nonhistones.

3. Histones and DNA have a strong attraction for each other because

C. DNA is negatively charged and histones are positively charged.

4. The first level of compaction of DNA consists of

A. DNA winding around histones to form small nucleosomes.

5. The histone that appears to be responsible for organizing the 100 Å fibers into 300 Å fibers is

H1

6. At what stage of mitosis do we first see a chromosome that is compacted 250-fold over the 40-fold compacted 300Å fiber?

Prophase

7. In higher eukaryotes, kinetochores attach to

C. multiple spindle fibers.

8. What are the four major classes of chromosomal rearrangements?

C. Deletions, inversions, duplications, reciprocal translocations.

9. The term for the type of mutation that results in a loss of material from the genome is

Deletion

10. An acentric fragment can be the result of crossing over between a normal chromosome and a chromosome that has undergone what kind of mutation?

A. paracentric inversion

11. FISH analysis would least likely be used to detect

Point Mutation

12. Robertsonian translocations result from which of the following?

A. Breaks occur at or near the centromeres of two acrocentric chromosomes followed by the reciprocal exchange of broken parts.

13. Down syndrome can result from

Trisomy 21

14. Barbara McClintock is most closely associated with which of the following?

B. the discovery of transposable elements in corn