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GI tract
Mouth
esophagus
stomach
small intestine
Duodenum
Jejunum
Ileum
large intestine
Cecum
Colon
Rectum
Appendix
anus
Function of saliva
Moisten food
Amylase in saliva → breaks down starch (chemical digestion)
Function of teeth & tongue
Teeth: mechanical digestion
Formation & movement of bolus
Tongue: pharyngeal phase of swallowing
Three phases of swallowing
Oral Phase: chewing/bolus
Pharyngeal phase: Bolus moved to back of mouth, nasopharynx closes
Esophageal phase: Peristalsis moves bolus through the esophagus
Function of stomach
Holding food for partial digestion
Producing gastric juices
Providing muscular action that, combined with gastric juice, mixes and tears food into smaller pieces (mechanical digestion)
Secreting the intrinsic factor/ Vitamin B12 absorption
Releasing Gastrin
Assisting in the destruction, through its acidity of secretions, of pathogenic bacteria that may have inadvertently been consumed
Duodenum (part of small intestine)
Mixed with enzymes from pancreas & bile from the gallbladder → break down food; absorption of water, iron, & some minerals
Jejunum
Inside walls absorb the food’s nutrients
Ileum
Absorbs bile acids → liver → made more bile → stored in the gallbladder for future use
Function of stomach
Final absorption of water & minerals
3 phases of gastric secretion
Cephalic (psychic phase): Gastrin stimulated
Gastric: Gastrin increases the release of gastric juices when food is present
Intestinal: Chyme (semi-liquid) formation
Aid Digestion
Hydrochloric Acid (HCL)
Pepsin
Intrinsic factor
Gastrin
Passive diffuse
Substances move from areas of high concentration to lower concentration (without ATP energy require)
Active transport
Substances move from lower concentration to higher concentration (Energy dependent active transport)
Catabolism
Break down (gluconeogenesis & glycogenolysis)
Anabolism
Building (lipogenesis)
Peristalsis
Contraction of muscle in the intestine & esophagus to push contents thru GI tract
Mechanical digestion
mouth and stomach
Chemical digestion
mouth, stomach, and small intestine
Population that are at greatest risk of vitamin deficiency
pregnant women
Older adults
Chronic alcohol and drug abuse
Poverty
Primary deficiency
Vitamin is not consumed in sufficient amounts to meet physiological needs
Secondary deficiency
Absorption is impaired or excess excretion occurs, limit bioavailability
strategies for assuring adequate vitamin intake
fresh fruits & vegetables
water soluble vitamins
vitamin c, choline, B complex (thiamin, riboflavin, niacin, folate, pyridoxine (b6), Vitamin b12, pantothenic acid, biotin)
Fat soluble vitamins
Vitamin A, D, E, K
Thiamin
water-soluble, Vitamin B1
Function of thiamin
Coenzyme, nerve and muscle functions
Deficiency symptoms of thiamin
Beriberi, Wernicke-Korsakoff syndrome, ataxia
Toxicity symptoms of Thiamin
Excess is excreted in urine
Food sources of thiamin
Lean pork, whole or enriched grains and flours, legumes, seeds, nuts
Riboflavin
water-soluble, vitamin B2
Function of Riboflavin
Coenzyme, releases energy from nutrients
Deficiency symptoms of Riboflavin
Ariboflavinosis, Cheilosis, Glossitis
Toxicity symptoms of riboflavin
None reported
Food sources of Riboflavin
Milk/ dairy products: meat, fish, poultry, eggs
Dark leafy greens
whole and enriched breads and cereals
Niacin
Water-soluble, B3
Function of Niacin
Coenzyme, used in glycolysis and the TCA cycle
Deficiency symptoms of Niacin
Pellagra, dermatitis, dementia, diarrhea
Toxicity symptoms of Niacin
Flushing
lowers LDL and increases HDL cholesterol
vasodilation
liver damage
gout
arthritic reactoins
Food sources of Niacin
Meats, poultry, fish, legumes, enriched cereals, milk, coffee, tea
Pyridoxine
water-soluble, vitamin B6
Function of Pyridoxine
Coenzyme in metabolizing amino acids and proteins
Deficiency symptoms for pyridoxine
dermatitis
altered nerve function
weakness
poor growth
convulsions
microcytic anemia
Toxicity symptoms of pyridoxine
Relieves premenstrual syndrome
Food sources of pyridoxine
Whole grains and cereals
legumes
chicken
fish
pork
eggs
Folate
Water-soluble, vitamin B9
Function of folate
Coenzymes, transfers one-carbon units during metabolism, forming fetal neural tubes
Deficiency symptoms of folate
Megaloblastic anemia
Toxicity symptoms of folate
Pernicious anemia
Food sources of Folate
Leafy green vegetables
legumes at cereals
some fruits and juices
Cobalamin
water-soluble, vitamin B12
Biotin
water-soluble, vitamin B7
Function of cobalamin
coenzyme, metabolizes folate
Deficiency symptoms of cobalamin
None
Toxicity symptoms of cobalamin
Pernicious anemia, CNS (central nervous system disease)
Food sources of cobalamin
animal sources
Function of biotin
Metabolism of carbohydrate, fat, and protein
deficiency symptoms of biotin
Produced by avidin and long-term antibiotics
Toxicity symptoms of biotin
None
Food sources of biotin
liver
kidney
peanut butter
egg yolks
intestinal synthesis
Pantothenic Acid
water-soluble, vitamin B5
function of pantothenic acid
part of coenzyme A
Deficiency symptoms of pantothenic acid
not possible
Toxicity symptoms of pantothenic acid
None
Food sources of pantothenic acid
widespread in foods
Choline
water-soluble
Function of choline
synthesis of acetylcholine and lecithin
Deficiency symptoms of choline
rare
Toxicity symptoms of choline
body odor
liver damage
hypotension
Food sources of choline
widespread (milk, eggs, peanuts)
Vitamin C
water-soluble, ascorbic acid
Function of Vitamin C
Antioxidant, coenzyme, collagen formation, wound healing, iron absorption, hormone synthesis
Deficiency symptoms of vitamin C
scurvy
Toxicity symptoms of vitamin C
cramps
Nausea
kidney stone formation
Gout (1-15g)
rebound scurvy
Food sources of vitamin C
fruits and vegetables
Vitamin A
Fat-soluble
Function of vitamin A
maintains epithelial tissues, rhodopsin formation for vision, bone growth, reproduction
Deficiency symptoms of Vitamin A
xeropthalmia
Night blindness
Keratomalacia
Degeneration of epithelial tissue
inhibited growth
Toxicity symptoms of Vitamin A
hypervitaminosis A with blistered skin, weakness, anorexia, vomiting, enlarged spleen and liver
Food sources of Vitamin A
Deep green, yellow, and orange fruits and vegetables
animal fat sources
Vitamin D
Fat-soluble
Function of Vitamin D
Calcium and phosphorus absorption; bone mineralization
Deficiency symptoms of vitamin D
Bone malformation
Rickets
Osteomalacia
Toxicity symptoms of Vitamin D
hypercalcemia
hypercalciuria
Food sources of Vitamin D
animal (fat) sources:
butter
egg yolks
fatty fish
liver
fortified milk
Vitamin E
Fat-soluble, alpha-tocopherol
Function of vitamin E
antioxidant for polyunsaturated fatty acid and vitamin A; antioxidant with selenium and ascorbic acid
Deficiency symptoms of Vitamin E
Primary deficiency rare
Secondary deficiency: caused by fat absorption
neurologic disorders
Toxicity symptoms for vitamin E
None (supplements contraindicated with anticoagulation drugs)
Food sources of Vitamin E
vegetable oil
whole grains
seeds
nuts
green leafy vegetables
Vitamin K
Fat-soluble
Function of vitamin K
Cofactor in the synthesis of blood clotting factors; protein formation
Deficiency symptoms of Vitamin K
Blood coagulation inhibited
hemorrhagic disease (infants)
Toxicity symptoms of vitamin K
Therapeutic vitamin K (menadione form) reactions in neonates, causing hemolytic anemia & hyperbilirubinemia
Food sources of vitamin K
Green leafy vegetables
intestinal synthesis
Adequate intake of daily fluids for adults
men: 13 cups
women: 9 cups
Percentage of the body weight that is water
Newborn infant: 75%-80%
Adult male: 55%-60%
Adult female: 50%-55%
Symptoms of dehydration/ fluid volume deficit
Infrequent urination
Decreased skin elasticity
Dry mucous membranes
Dry mouth
Unusual drowsiness
Lighten headedness
Disorientation
Extreme thirst
Nausea
Sudden weight loss
slow/ rapid breathing
Hard water
Contains high amounts of minerals (mineral deposits may damage appliances & machinery)
Soft water
Replace some minerals in hard water with sodium (A problem for sodium-sensitive individuals)
Intracellular (within cell) 65% of body water
enzymes
hemoglobin
magnesium
minerals
phosphorus
potassium
proteins
Interstitial fluids
Between cells