Intro to Rheumatology

characteristics of the immune system

innate v. adaptive immunity

systemic inflammatory response

acute phase reactants (APRs)

induction of acute phase reactants (*key point)

how do we measure inflammation?

laboratory measures of APRs (*)

laboratory measures of APRs- CRP

fever during infection

mechanism- fever during infection (*)

mechanism- fever during chronic inflammatory disease (*)

anemia of chronic inflammation (aka anemia of chronic disease)

hepcidin (*)

function of hepcidin (*)

hepcidin and anemia (*)

anemia of inflammation

cachexia- loss of muscle driven by chronic inflammation (*)

atherogenesis/thrombosis (*)

atherogenesis/thrombosis- chronic inflammation (*)

links between inflammation and thrombosis

auto-inflammation (*)

inflammasome

familial mediterranean fever (FMF)

adult onset still’s disease

adult onset still’s disease progression and treatment

systemic juvenile idiopathic arthritis (sJIA)

macrophage activation syndrome (*)

summary