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emergent properties
combo & synergism of actions of the components of a system
physiology of the human body > than the sum of the actions of its parts
cell, tissues and systems are all integrated
epithelial, connective, muscle, nervous
What are the 4 primary tissue types?
Teleologic Approach
the "why", why does something occur
Mechanic Approach
the "how", how something occurs
circulatory system
Transport and distribution of various substances throughout like oxygen, hormones, nutrients, etc throughout body
digestive system
breakdown of foods/nutrients and absorption
endocrine system
communication throughout body (slow and long lasting)
immune system
lymph, protection
integumentary system
protection, barrier, some exchange, some regulation, some excretion
musculoskeletal system
support and movement, temp reg, excretion
nervous system
communication; coordination; regulation (instant/fast)
reproductive system
reproduction
respiratory system
gas exchange and excretion
urinary system
excretion; water balance
excretion
Process by which metabolic wastes are eliminated from the body
secretion
the substance produced by a gland
structure and function
which major theme in physio:
- links anatomy and physio
- shape determines what it does
need for energy
which major theme in physio:
- cell/organism growth, reproduction, movement and homeostasis
communication/coordination
which major theme in physio:
- genetic: DNA & RNA
- chemical signals
- electrical signals
homeostasis
which major theme in phsyio:
- maintaining relatively constant internal conditions regardless of external environment
It's how the body is able to function as a whole and be successful as a multi-cellular organism
Why are the themes of physio so important to body function?
physiology
the study of the normal functions of the body
Pathophysiology
The study of how normal physiologic processes are affected by disease.
failure in physio:
- diabetes
- cancer cells
- genetic diseases
- allergies (autoimmune)
What are some examples of internal sources of pathophysiology?
damage to physio:
- trauma impacting body
- pathogen (viruses, bacteria, etc.)
What are some examples of external sources of pathophysiology?
Intercellular Fluid (ICF)
fluid within cells; intercellular fluid
extracellular fluid (ECF)
fluid outside cells; plasma and interstitial fluid
What goes into the body = what goes out of the body
intake - inhaling, digestion/absorption
excretion - sweat, defecation/urination/exhaling
positive balance - taking more in than out
negative balance - ridding more than taking in
stable - normal function, in=out
Explain the Law of Mass Balance or Stable Balance including mechanisms used to get material into and out of the body
- explain circumstances that lead to a positive, negative, or stable balance
Homeostasis
- dynamic steady state
- maintain relatively constant conditions
- no net movement
- disequilibrium (concentrations are not equal between compartments)
Equilibrium
- equal balance
- concentrations are equivalent between compartments
What is the difference between homeostasis VS equilibrium?
setpoint
a value at which physiological state tends to stabilize at
Homeostasis range
a range of values at which a physiological state is considered stable
control system
collection of interconnected components that can be made up to achieve a desired response
local control
this control of homeostasis is within the cell or tissues
ex: paracrine & autocrine cells
- arteriole endothelium and nitric oxide (NO) are vasodialater (increases blow flow)
reflex control
the control of homeostasis is long distance
- integration into nervous, endocrine, or both
- neurotransmitters and hormones
negative feedback loop
brings back to homeostasis (on then off)
- stabilizes regulated variable
- a response counteracts the stimulus, shuts off loop
ex: insulin & glucose levels
positive feedback loop
gets further away from homeostasis
- sends variable farther from the setpoint
- on and reinforce to completion
- ex: childbirth
feedforward control
actions due to anticipation of change of the regulated variable
gets you ready for what is coming; signals tell you something is going to happen and your body prepares
- salivation & activation of parietal cells in stomach to secrete HCl acid
yes
Can feedforward control help maintain homeostasis?
there are short term variations within what is normal but it will move back to middle stable ground and balance out (blood glucose levels)
How does homeostasis function as a dynamic steady state?
biological rhythms
natural cycles the body uses to regulate different bodily functions
- set points can change
ex: going to bed every night at 10 pm, switching jobs and having to go to bed at 8 pm instead.
biorhytm
predictable; fluctuate with environment variable
ex: light/dark cycles, seasonal
circadian rhythm
daily rhythms
- free running vs. entrained (can be reset based on environmental cues)
free running (our own internal clock)
entrained (what the clock tell us)
Acclimization
adjusted setpoints based upon environmental conditions
- seasons and clothing
ex: 60 degrees in winter is warm
60 degrees in summer is cold