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Last updated 4:51 AM on 10/23/23
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122 Terms

1
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What are the different blood types according to the ABO blood typing system? What antigens/antibodies?

  • Type A

    • Antigen A

    • Anti-B antibodies

    • (+/-) if presence of antigen D

  • Type B

    • Antigen B

    • Anti-A antibodies

  • Type AB

    • Antigen A

    • Antigen B

    • no Antibodies

  • Type O

    • no Antigen

    • Anti-A antibodies

    • Anti-B antibodies

<ul><li><p>Type A</p><ul><li><p>Antigen A</p></li><li><p>Anti-B antibodies</p></li><li><p>(+/-) if presence of antigen D</p></li></ul></li><li><p>Type B</p><ul><li><p>Antigen B</p></li><li><p>Anti-A antibodies</p></li></ul></li><li><p>Type AB</p><ul><li><p>Antigen A</p></li><li><p>Antigen B</p></li><li><p>no Antibodies</p></li></ul></li><li><p>Type O</p><ul><li><p>no Antigen</p></li><li><p>Anti-A antibodies</p></li><li><p>Anti-B antibodies</p></li></ul></li></ul>
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What is the Rh factor?  What makes blood Rh positive?

  • Rh factor aka D antigen

  • Rh +

    • Antigen D

    • No anti-D antibodies

  • Rh -

    • no antigen D

    • no anti-D antibodies (unless exposed to Rh+ blood)

<ul><li><p>Rh factor aka D antigen</p></li><li><p>Rh +</p><ul><li><p>Antigen D</p></li><li><p>No anti-D antibodies</p></li></ul></li><li><p>Rh -</p><ul><li><p>no antigen D</p></li><li><p>no anti-D antibodies (unless exposed to Rh+ blood)</p></li></ul></li></ul>
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Complete a table of ABO blood types including its Rh factor.  Add which can donate to whom and receive from whom safely.

BLOOD TYPE

CAN GIVE TO

CAN RECEIVE FROM

A+

A+, AB+

A+, A-, O+, O-

A-

A+, A-, AB+, AB-

A-, O-

B+

B+, AB+

B+, B-, O+, O-

B-

B+, B-, AB+, AB-

B-, O-

AB+

AB+

EVERYONE

AB-

AB+, AB-

AB-, A-, B-, O-

O+

O+, A+, B+ AB+

O+, O-

O-

EVERYONE

O-

<table><tbody><tr><td colspan="1" rowspan="1"><p><strong>BLOOD TYPE</strong></p></td><td colspan="1" rowspan="1"><p><strong>CAN GIVE TO</strong></p></td><td colspan="1" rowspan="1"><p><strong>CAN RECEIVE FROM</strong></p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>A+</strong></p></td><td colspan="1" rowspan="1"><p>A+, AB+</p></td><td colspan="1" rowspan="1"><p>A+, A-, O+, O-</p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>A-</strong></p></td><td colspan="1" rowspan="1"><p>A+, A-, AB+, AB-</p></td><td colspan="1" rowspan="1"><p>A-, O-</p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>B+</strong></p></td><td colspan="1" rowspan="1"><p>B+, AB+</p></td><td colspan="1" rowspan="1"><p>B+, B-, O+, O-</p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>B-</strong></p></td><td colspan="1" rowspan="1"><p>B+, B-, AB+, AB-</p></td><td colspan="1" rowspan="1"><p>B-, O-</p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>AB+</strong></p></td><td colspan="1" rowspan="1"><p>AB+</p></td><td colspan="1" rowspan="1"><p>EVERYONE</p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>AB-</strong></p></td><td colspan="1" rowspan="1"><p>AB+, AB-</p></td><td colspan="1" rowspan="1"><p>AB-, A-, B-, O-</p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>O+</strong></p></td><td colspan="1" rowspan="1"><p>O+, A+, B+ AB+</p></td><td colspan="1" rowspan="1"><p>O+, O-</p></td></tr><tr><td colspan="1" rowspan="1"><p><strong>O-</strong></p></td><td colspan="1" rowspan="1"><p>EVERYONE</p></td><td colspan="1" rowspan="1"><p>O-</p></td></tr></tbody></table>
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ABO blood type compatibility

  • O

    • receive blood from O

  • A

    • receive blood from O and A

  • B

    • receive blood from O and B

  • AB

    • receive blood from all

<ul><li><p>O</p><ul><li><p>receive blood from O</p></li></ul></li><li><p>A</p><ul><li><p>receive blood from O and A</p></li></ul></li><li><p>B</p><ul><li><p>receive blood from O and B</p></li></ul></li><li><p>AB</p><ul><li><p>receive blood from all</p></li></ul></li></ul>
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Rh blood type compatibility

  • +

    • can give to +

  • -

    • can give to + and -

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Most common blood type

O+

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Rarest blood type

AB-

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Universal donor blood type

O-

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Universal receiver blood type

AB+

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What is erythroblastosis fetalis/hemolytic disease of the newborn?  What is the typical scenario that can lead to this condition (Rh of mother, father and baby)?

  • When mother (Rh-) develops anti-D antibodies when exposed to baby’s blood (Rh+) which will attack the next baby (Rh+)

  • Father Rh+

  • Mother Rh-

  • Babies Rh+

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Can we prevent erythroblastosis fetalis?  If yes, how?

  • administration of exogenous Rh immune globulin to mother

    • @26-28 wks of pregnancy

    • within 72 hr of delivery

  • to prevent mother from developing anti-D antibodies

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What is agglutination reaction?

RBC sticking together because of antigen-antibody binding

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In a blood typing test, what anti-sera and blood type combination will result to clumping/agglutination?  Give examples.

  • Type A

    • Anti-A serum clumping

    • no anti-b serum clumping

  • Type B

    • no anti-a serum clumping

    • Anti-B serum clumping

  • Type AB

    • Anti-A serum clumping

    • Anti-B serum clumping

  • Type O

    • no clumping

  • Rh+

    • clumping

  • Rh-

    • no clumping

<ul><li><p>Type A</p><ul><li><p><strong>Anti-A serum clumping</strong></p></li><li><p>no anti-b serum clumping</p></li></ul></li><li><p>Type B</p><ul><li><p>no anti-a serum clumping</p></li><li><p><strong>Anti-B serum clumping</strong></p></li></ul></li><li><p>Type AB</p><ul><li><p><strong>Anti-A serum clumping</strong></p></li><li><p><strong>Anti-B serum clumping</strong></p></li></ul></li><li><p>Type O</p><ul><li><p>no clumping</p></li></ul></li><li><p>Rh+</p><ul><li><p><strong>clumping</strong></p></li></ul></li><li><p>Rh-</p><ul><li><p>no clumping</p></li></ul></li></ul>
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What are the two main categories of WBCs?  Categorize the WBCs, describe each in detail and draw them.

  • granulocytes (BEN)

    • basophils

    • eosinophils

    • neutrophils

  • agranulocytes (LM)

    • lymphocytes

      • smaller, round nuclei

    • monocytes

      • larger, kidney shaped nuclei

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most and least common leukocytes

  • neutrophils = 40-70%

  • lymphocytes = 20-40%

  • basophils = 0-1%

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Which WBC is phagocytic

  • monocytes

  • neutrophils

  • eosinophils

  • basophils

  • (aka all except lymphocytes)

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Average WBC count

  • 5,000-10,000/mm3

  • Neutrophils

    • 55-75%

  • Lymphocytes

    • 20-40%

  • Monocytes

    • 3-8%

  • Eosinophils

    • 2-4%

  • Basophils

    • 0.5-1%

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Meaning of CBC with diff

  • CBC = complete blood count of white cells in blood

  • CBC w/ diff = measure of each type of WBC

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Define the following WBC response to inflammation terms:  diapedesis, adhesion, phagocytosis, rolling, capture

  • Diapedesis

    • when WBC squeeze through tiny blood vessel walls to reach site of infection or injury

    • neutrophils + monocytes

  • Adhesion

    • WBC stick to the inner blood vessel walls near inflammation site, preparing to exit bloodstream

    • neutrophils + monocytes

  • Phagocytosis

    • WBC engulf and EAT harmful invaders like bacteria or debris to remove them from the body

    • neutrophils + monocytes

  • Rolling

    • WBC lightly stick to blood vessel walls and slowly move along to find best spot to exit

    • neutrophils + monocytes

  • Capture

    • WBC are temporarily caught by the blood vessel walls, helping them get ready to leave bloodstream and enter affected area

    • all WBC

20
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explain diapedesis as a WBC response to inflammation

  • Diapedesis

    • when WBC squeeze through tiny blood vessel walls to reach site of infection or injury

    • neutrophils + monocytes

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explain adhesion as a WBC response to inflammation

  • Adhesion

    • WBC stick to the inner blood vessel walls near inflammation site, preparing to exit bloodstream

    • neutrophils + monocytes

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explain phagocytosis as a WBC response to inflammation

  • Phagocytosis

    • WBC engulf and EAT harmful invaders like bacteria or debris to remove them from the body

    • neutrophils + monocytes

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explain rolling as a WBC response to inflammation

  • Rolling

    • WBC lightly stick to blood vessel walls and slowly move along to find best spot to exit

    • neutrophils + monocytes

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explain capture as a WBC response to inflammation

  • Capture

    • WBC are temporarily caught by the blood vessel walls, helping them get ready to leave bloodstream and enter affected area

    • all WBC

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What are the cardinal signs of inflammation?

  • Edema (tumor)

  • Redness (rubor)

  • Pain (dolor)

  • Heat (calor)

  • Loss of function

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Where can you find lymphocytes?  What are T cells?  What are B cells?  Differentiate between the two.

  • lymphocytes are found in thymus, lymph nodes and spleen

  • Thymus derived lymphocytes = T cells

  • Bone marrow derived lymphocytes = B cells

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Function of neutrophils

  • help body fight off bacterial + fungal infections by phagocytosis

  • phagocytosis + release of enzymes and antimicrobial peptides

  • releases NETS (neutrophil extracellular traps)

  • apoptosis (programmed cell death)

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What is antigen, antibody, epitope and immunity?

  • antigen

    • molecules that activate the immune system

  • antibody

    • recognize and combat harmful substances in body

  • epitope

    • spot on pathogen that antibodies bind to to make pathogen a target

  • immunity

    • body’s ability to defend itself against harmful invaders

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What is the “lock and key” model of antibody structure?

  • lock = unique shape of antigen

  • key = identical shape of antibody’s antigen-binding site

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Difference between B and T cells

  • B cells

    • humoral immunity

    • secretes antibody

    • develop into plasma cells

    • bacterial infections

    • types of destruction

      • phagocytic - antibodies coat bacterial cell

      • complement system - attachment of antibody to antigen

  • T cells

    • cell mediated immunity

    • doesn’t secrete antibody

    • must be close to victim cells to destroy

    • viruses, cancer cells, and cells of tissue transplants

    • 3 types

      • Killer (Cytotoxic) T cells – kill victim cells

      • Helper T cells – promote the activity of killer T cells and B cells

      • Regulatory (suppressor) T cells – dampen immune responses

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ECG stands for

electrocardiogram

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What is an ECG?  What does it show?

  • A recording of electrical events of the heart

  • Mainly records heart rate and rhythm to check for irregularity

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What is the rationale behind ECG?

  • body fluids has high concentration of electrolytes. The electrical activity generated by heart travels throughout the body.  This activity is then monitored by placing a pair of electrodes on different areas of the skin.

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What are the basic concepts that are important to know about the heart?

  • The chambers

  • The valves

  • The great vessels

  • Oxygenated and deoxygenated blood

  • Systole and diastole

  • Pacemaker

  • Pulmonary and systemic circulation

<ul><li><p><span style="font-family: Calibri, sans-serif">The chambers</span></p></li><li><p><span style="font-family: Calibri, sans-serif">The valves</span></p></li><li><p><span style="font-family: Calibri, sans-serif">The great vessels</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Oxygenated and deoxygenated blood</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Systole and diastole</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Pacemaker</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Pulmonary and systemic circulation</span></p></li></ul>
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Define the cardiac cycle terms:  systole, diastole, automaticity, rhythmicity

  • Systole- contraction phase

    • Depolarization → contraction → systole

  • Diastole- relaxation phase

    • Repolarization → relaxation → diastole

  • Automaticity - able to stimulate itself electrically in the absence of neural input (involuntary) (unlike skeletal muscle)

  • Rhythmicity- having a regular, repeated pattern

    • Intrinsic regulation of systole and diastole

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Enumerate the different heart valves, their other names, shape, location in the heart.

  • Atrioventricular valves (AV valves)

    • Mitral (bicuspid) valve

      • Located between L atrium and L ventricle

      • Shape resembles mitre hat

    • Tricuspid valve

      • Located between R atrium and R ventricle

  • Semilunar valves (SL valves)

    • Aortic valve

      • Located between L ventricle and aorta

    • Pulmonary valve

      • Located between R ventricle and pulmonary artery

<ul><li><p><strong><span style="font-family: Calibri, sans-serif">Atrioventricular valves (AV valves)</span></strong></p><ul><li><p><strong><span style="font-family: Calibri, sans-serif">Mitral (bicuspid) valve</span></strong></p><ul><li><p><span style="font-family: Calibri, sans-serif">Located between L atrium and L ventricle</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Shape resembles mitre hat</span></p></li></ul></li><li><p><strong><span style="font-family: Calibri, sans-serif">Tricuspid valve</span></strong></p><ul><li><p><span style="font-family: Calibri, sans-serif">Located between R atrium and R ventricle</span></p></li></ul></li></ul></li><li><p><strong><span style="font-family: Calibri, sans-serif">Semilunar valves (SL valves)</span></strong></p><ul><li><p><strong><span style="font-family: Calibri, sans-serif">Aortic valve</span></strong></p><ul><li><p><span style="font-family: Calibri, sans-serif">Located between L ventricle and aorta</span></p></li></ul></li><li><p><strong><span style="font-family: Calibri, sans-serif">Pulmonary valve</span></strong></p><ul><li><p><span style="font-family: Calibri, sans-serif">Located between R ventricle and pulmonary artery</span></p></li></ul></li></ul></li></ul>
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What is the normal pacemaker of the heart?  Write down the steps in heart conduction.

  • Sinoatrial Node (SA node)

    • Wave of depolarization easily spread across the R and L atria

  • Steps of heart conduction

    • SA node fires →

    • Excitation spreads through atrial myocardium →

    • AV node fires →

    • Excitation spreads down AV bundle →

    • Purkinje fibers distribute excitation through ventricular myocardium

<ul><li><p><span style="font-family: Calibri, sans-serif">Sinoatrial Node (SA node)</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">Wave of depolarization easily spread across the R and L atria</span></p></li></ul></li><li><p><span style="font-family: Calibri, sans-serif">Steps of heart conduction</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">SA node fires →</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Excitation spreads through atrial myocardium →</span></p></li><li><p><span style="font-family: Calibri, sans-serif">AV node fires →</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Excitation spreads down AV bundle →</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Purkinje fibers distribute excitation through ventricular myocardium</span></p></li></ul></li></ul>
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Compare and contrast systemic circulation and pulmonary circulation

  • Systemic circulation

    • Circulated oxygenated blood across the rest of the body

  • Pulmonary circulation

    • Moves blood between heart and lungs

    • Deoxygenated blood → lungs, oxygenated blood → heart

    • Pulmonary artery → lungs → pulmonary veins

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How many limb leads are there in an ECG?  How about how many unipolar leads?  How many chest leads?  How many leads all in all?

  • 6 limb/bipolar leads

  • 6 chest/unipolar leads V1-6

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The ECG has different waves.  What do these waves represent:  P wave, QRS complex, T wave and U wave?

  • P wave → QRS complex → T wave → U wave

  • P wave

    • Atrial depolarization

  • QRS complex

    • Ventricular depolarization

  • T wave

    • Repolarization of the ventricles at the beginning of diastole

  • U wave

    • Incompletely understood

<ul><li><p><span style="font-family: Calibri, sans-serif">P wave → QRS complex → T wave → U wave</span></p></li><li><p><span style="font-family: Calibri, sans-serif">P wave</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">Atrial depolarization</span></p></li></ul></li><li><p><span style="font-family: Calibri, sans-serif">QRS complex</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">Ventricular depolarization</span></p></li></ul></li><li><p><span style="font-family: Calibri, sans-serif">T wave</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">Repolarization of the ventricles at the beginning of diastole</span></p></li></ul></li><li><p><span style="font-family: Calibri, sans-serif">U wave</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">Incompletely understood</span></p></li></ul></li></ul>
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What information can be provided by an ECG?

  • HR

    cardiac hypertrophy

    necrosis

    ischemia

    other conditions that may produce abnormalities of electrical conduction

    heart rhythm

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How are heart sounds produced?

  • Contraction and relaxation of ventricles →

  • Pressure changes →

  • One-way heart valves will close →

  • Heart sound

    • Produced by closing valves

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What is S1?  How about S2?  Which valves closes in S1 and in S2?  Which one is the “lub”?  Which one is the “dub”?  Are they normal heartbeats or not?

  • S1 is the first heart sound, S2 is the second

  • S1 = Lub

    • Closure of AV valves (atrioventricular valves)

      • MV + TV

      • ventricle contracts/systole

  • S2 = Dub

    • Closure of SL valves (semilunar valves)

      • AV + PV

      • ventricles relax/diastole

  • These are the sounds of normal heartbeats

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Give examples of abnormal heart beats?

  • Heart murmurs

    • Valve irregularity, septal defect, persistent fetal opening (foramen ovale) between the right and left atria after birth

  • Mitral valve prolapse

    • Most common cause of chronic mitral regurgitation, where blood flows backward into left atrium

    • Can be congenital or acquired, people may live without symptoms, and others may need mitral valve to be repaired or replaced

<ul><li><p><span style="font-family: Calibri, sans-serif">Heart murmurs</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">Valve irregularity, septal defect, persistent fetal opening (foramen ovale) between the right and left atria after birth</span></p></li></ul></li><li><p><span style="font-family: Calibri, sans-serif">Mitral valve prolapse</span></p><ul><li><p><span style="font-family: Calibri, sans-serif">Most common cause of chronic mitral regurgitation, where blood flows backward into left atrium</span></p></li><li><p><span style="font-family: Calibri, sans-serif">Can be congenital or acquired, people may live without symptoms, and others may need mitral valve to be repaired or replaced</span></p></li></ul></li></ul>
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Where to place stethoscope for both heart sounds?

  • S1 Lub

    • Left 5th intercostal space, MCL

      • MCL = midclavicular line

  • S2 Dub

    • Right and left 2nd intercostal space (both sides)

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Where to place stethoscope to best hear valves?

  • AV aortic valve

    • R 2nd ICS (near sternum)

  • PV pulmonary valve

    • L 2nd ICS (near sternum)

  • BV bicuspid valve

    • L 5th ICS

  • TV tricuspid valve

    • L 5th ICS MCL (midclavicular line)

<ul><li><p>AV aortic valve</p><ul><li><p>R 2nd ICS (near sternum)</p></li></ul></li><li><p>PV pulmonary valve</p><ul><li><p>L 2nd ICS (near sternum)</p></li></ul></li><li><p>BV bicuspid valve</p><ul><li><p>L 5th ICS</p></li></ul></li><li><p>TV tricuspid valve</p><ul><li><p>L 5th ICS MCL (midclavicular line)</p></li></ul></li></ul>
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 What is spirometry and what does it measure?

Spirometry or lung function test.

Measure:
lung volumes and capacities

ventilation as a function of time

lung function or lung health
(lung, chest wall and respiratory muscles) 

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What are the parts of a spirometer?

Spirometer– is the apparatus
–volume indicator scale

–drum retainer

–floating bell

–water tank

– hose/tube

– single use mouthpiece

<p><span style="font-family: Calibri, sans-serif">Spirometer– is the apparatus<br>–volume indicator scale</span></p><p><span style="font-family: Calibri, sans-serif">–drum retainer</span></p><p><span style="font-family: Calibri, sans-serif">–floating bell</span></p><p><span style="font-family: Calibri, sans-serif">–water tank</span></p><p><span style="font-family: Calibri, sans-serif">– hose/tube</span></p><p><span style="font-family: Calibri, sans-serif">– single use mouthpiece</span></p>
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 Enumerate the different volumes and capacities.  Define each, state normal values (if discussed) and formulas.

  • (TV) Tidal Volume

    • –- represents the normal volume of air inspired and expired during each normal (unforced) ventilation cycle

      • Normal TV = 500 mL

  • (RV) Residual Volume

    • – volume of air REMAINING in the lungs after a maximum (forced) exhalation

      • Cannot be measured using expiration-only spirometers

      • RV = VC X age factor

  • (IRV) Inspiratory Reserve Volume

    • – MAXIMUM volume of air that can be FORCEFULLY inhaled after normally (unforced) inhalation

      • Cannot be measured using expiration-only spirometers

      • IRV = VC - ERV - TV

  • (ERV) Expiratory Reserve Volume

    • – is the MAXIMUM volume of gas that can be FORCEFULLY EXHALED after a normal exhalation

      • Normal ERV = 1,200 mL

  • (VC) Vital Capacity

    • –MAXIMUM volume of air that can be exhaled after maximum (forced) inhalation

      • Normal VC is based on GENDER , AGE and HEIGHT in cm

      • VC= IRV + TV= ERV

  • (IC) Inspiratory Capacity

    • – MAXIMUM volume of air that can be inhaled after normal (unforced) exhalation

  • (FRC) Functional Residual Capacity

    • – volume of air REMAINING in the lungs after a normal (unforced) exhalation

  • (TLC) Total Lung Capacity

    • – TOTAL VOLUME of air in the lungs after maximum inhalation

    • – Maximum volume of air the lungs can accommodate

    • – Sum of all volume compartments

      • Cannot be measured using expiration-only spirometers

      • TLC = VC X age factor

    • TLC = TV + IRV + ERV + RV

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What is TV tidal volume and possible formulas

  • (TV) Tidal Volume

    • –- represents the normal volume of air inspired and expired during each normal (unforced) ventilation cycle

      • Normal TV = 500 mL

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What is RV residual volume and possible formulas

  • (RV) Residual Volume

    • – volume of air REMAINING in the lungs after a maximum (forced) exhalation

      • Cannot be measured using expiration-only spirometers

      • RV = VC X age factor

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What is IRV Inspiratory Reserve volume and possible formulas

  • (IRV) Inspiratory Reserve Volume

    • – MAXIMUM volume of air that can be FORCEFULLY inhaled after normally (unforced) inhalation

      • Cannot be measured using expiration-only spirometers

      • IRV = VC - ERV - TV

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What is ERV Expiratory Reserve volume and possible formulas

  • (ERV) Expiratory Reserve Volume

    • – is the MAXIMUM volume of gas that can be FORCEFULLY EXHALED after a normal exhalation

      • Normal ERV = 1,200 mL

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What is VC Vital Capacity and possible formulas

  • (VC) Vital Capacity

    • –MAXIMUM volume of air that can be exhaled after maximum (forced) inhalation

      • Normal VC is based on GENDER , AGE and HEIGHT in cm

      • VC= IRV + TV= ERV

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What is IC Inspiratory Capacity and possible formulas

  • (IC) Inspiratory Capacity

    • – MAXIMUM volume of air that can be inhaled after normal (unforced) exhalation

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What is FRC Functional Residual Capacity and possible formulas

  • (FRC) Functional Residual Capacity

    • – volume of air REMAINING in the lungs after a normal (unforced) exhalation

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What is TLC Total Lung Capacity and possible formulas

  • (TLC) Total Lung Capacity

    • – TOTAL VOLUME of air in the lungs after maximum inhalation

    • – Maximum volume of air the lungs can accommodate

    • – Sum of all volume compartments

      • Cannot be measured using expiration-only spirometers

      • TLC = VC X age factor

    • TLC = TV + IRV + ERV + RV

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 Your lung volumes and capacities are considered normal If your score is
_______ of the predicted value?

 Your lung volumes and capacities are considered normal If your score is
> 80 % of the predicted value?

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What is Boyle’s Law?  Apply Boyle’s Law during inhalation?  How about during exhalation?

  • The PRESSURE of gas is INVERSELY PROPORTIONAL to its VOLUME

  • Inhalation:

    • thoracic cavity volume ↑

    • intrapulmonary pressure ↓ and air flows into the lungs

  • Exhalation:

    • thoracic cavity volume ↓

    • intrapulmonary pressure ↑ and air exits the lungs

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 What is the anatomic division of the respiratory system?  What are the structures in each division?

 ANATOMICALLY: divided into upper and lower respiratory tracts

  • upper respiratory tract

    • nasal cavity, pharynx, larynx

  • lower respiratory tract

    • trachea, bronchi, lungs

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What is the functional division of the respiratory system?  What are the structures in each division?

FUNCTIONALLY: divided into a conducting portion (where only air transport occurs) and a respiratory portion (where gas exchange occurs)

  • conducting zone

    • nasal cavity, pharynx, trachea, bronchi, bronchioles

  • respiratory zone

    • bronchioles, alveolar ducts and sacs, alveoli

<p><span style="font-family: Calibri, sans-serif">FUNCTIONALLY: divided into a conducting portion (where only air transport occurs) and a respiratory portion (where gas exchange occurs)</span></p><ul><li><p>conducting zone</p><ul><li><p>nasal cavity, pharynx, trachea, bronchi, bronchioles</p></li></ul></li><li><p>respiratory zone</p><ul><li><p>bronchioles, alveolar ducts and sacs, alveoli</p></li></ul></li></ul>
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 Define pulmonary ventilation

 Is the movement of air into and out of the respiratory system, inhalation/exhalation

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Define gas exchange

  • External respiration exchanges gases between atmosphere —> blood (in the lungs)

  •  Internal respiration exchanges gases between blood —> body’s cells

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What are the two muscles of quiet breathing?

 Skeletal muscles of QUIET BREATHING include diaphragm and external intercostals
– contraction → inhalation
– relaxation → exhalation

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What are the volume changes in the thoracic cavity that occur during inhalation and exhalation?

  • During inhalation and exhalation, the thoracic cavity changes in ALL three dimensions

    • Vertical changes result from diaphragm movement

    • Lateral changes result from the rib cage elevation or depression

    • Anterior-posterior changes occur as the sternum moves anteriorly or posteriorly

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What is blood pressure

The measurement of force applied to artery walls

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What is the equation for blood pressure in relation to cardiac output, total peripheral resistance, heart rate and stroke volume?

BP = CO x TPR

CO = HR x SV

  • BP = blood pressure

  • CO = cardiac output

    • vol of blood pumped per min

  • TPR = total peripheral resistance

  • HR = heart rate, SV = stroke volume

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Which artery do you auscultate when taking the blood pressure?

brachial artery

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What is Korotkoff sound?

 It is heard when there is turbulent blood flow through a constriction in the brachial artery

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Compare and contrast laminar flow with turbulent flow when taking the blood pressure

  • Laminar (“layered”) flow–occurs when all parts of a fluid move in the same direction, parallel to the axis of the vessel.

  • Turbulent flow occurs when some parts of the fluid move in radial and circumferential directions, churning and mixing the blood.


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 Enumerate the instructions or questions you should ask/give your patient before taking his/her blood pressure?

  • Patient should relax for at least 5 minutes.

  • Smoking, exercise, drinking caffeinated and alcoholic drinks, full stomach,full bladder, extreme temperature–relax for at least 30 minutes.

  • Patient should sit with back straight and supported.

  • Feet flat on floor and uncrossed.

  • Remove excess clothing that might interfere BP cuff or constrict the arm.

  • *Pain can increase BP

  • *Use appropriate size BP cuff (pediatric BP cuff, adult and XL)

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What is the importance of taking the palpatory BP first

The importance of taking the palpatory first is because it helps establish a baseline before using a blood pressure clift. 

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What is pulse pressure and its formula?

  • Pulse pressure is the “gap” between the highest and lowest blood pressure numbers.

  • Formula: Pulse Pressure = SBP-DBP

    • systolic bp - diastolic bp

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What is mean arterial pressure and its formula?

  • The average pressure in a person’s arteries during one heartbeat.

  • Formula: MAP= ⅓ PULSE PRESSURE+DBP

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  What is hypertension?

May be indicated by chronically elevated blood pressure measurements 

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 What are the two main categories of hypertension?  Compare and contrast each category.

 The two main categories of hypertension are Primary and Secondary Hypertension.

  • Primary hypertension is common and has no specific cause.

  • Secondary hypertension is less common and caused by a specific medical condition.

  • They both are conditions characterized by high blood pressure. 

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Blood pressure classification table in adults

  • Optimal

    • SBP = <120

    • DBP = <80

  • Normal

    • SBP = 120-129

    • DBP = 80-84

  • High normal

    • SBP = 130-139

    • DBP = 85-89

  • Grade 1 hypertension

    • SBP = 140-159

    • DBP = 90-99

  • Grade 2 hypertension

    • SBP = 160-179

    • DBP = 100-109

  • Grade 3 hypertension

    • SBP = >= 180

    • DBP = >= 110

  • Isolated systolic hypertension

    • SBP = >= 140

    • DBP = <90

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 What are the 3 body controls of acid-base balance?

  • lung

  • kidney

  • bicarbonate system

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What is pH?  What is the pH of pure water?

Concentration of hydrogen ions (H^+) in a solution

Pure water is 7 ( neutral solution)

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What is a buffer?  What is the major buffer of blood?

A solution that resists changes in pH when an acid or alkali is added to it. 

To keep pH at a nearly constant value

bicarbonate

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 What is the normal blood pH?

7.35-7.45

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What is an acid?

A molecule that can donate free H+ to a solution and LOWER its pH

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What happens to our acid-base balance during hypoventilation + hyperventilation

  • Hypoventilation

    • → CO2 is not all blown off

    • →  CO2 accumulates in the blood​

    • →decrease in blood pH ​

    • →Respiratory acidosis​

  • Hyperventilation

    • → low CO2 levels in blood

    • → Respiratory alkalosis

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What happens to acid-base balance when we exercise?

  • Exercise Hyperpnea– deep breathing (+/- increase RR)

  • Does it produce respiratory alkalosis?

    • Does not produce respiratory alkalosis

    • Is matched with increased product CO2 during exercise

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 Think of situations where respiratory acidosis can happen?  How about situations where respiratory alkalosis can happen?

  • Respiratory acidosis is a medical condition that occurs when the lungs are unable to remove enough carbon dioxide from the body, leading to an increase in blood acidity

    • hypoventilation

  • Respiratory alkalosis is a condition in which the blood pH becomes too high due to low levels of carbon dioxide

    • hyperventilation

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What makes a blood type O?

  1. absence of O antibody

  2. absence of a and b antigen

  3. none

  4. absence of a and b antibody

  5. presence of o antibody

  6. absense of B antibody

  1. absence of O antibody

  2. absence of a and b antigen

  3. none

  4. absence of a and b antibody

  5. presence of o antibody

  6. absense of B antibody

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The statement, "there are more people with Rh (-) blood than people with Rh (+) blood", is ____________________________________.

  • true

  • false

false

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Which is responsible for programmed cell death or apoptosis?

  • neutrophils

  • all are correct

  • lymphocytes

  • monocytes

  • basophils

  • eosinophils

  • none

  • neutrophils

  • all are correct

  • lymphocytes

  • monocytes

  • basophils

  • eosinophils

  • none

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In simple terms, what is the "lock and key" model of antibody structure?

  • the antibody is the key that will unlock the antigen in the bacteria

  • none

  • antibody must match antigen epitope in order to result in binding

  • antibody must open the lock of the antigen in order to result in untangling

  • the antibody is the key that will unlock the antigen in the bacteria

  • none

  • antibody must match antigen epitope in order to result in binding

  • antibody must open the lock of the antigen in order to result in untangling

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There are two ways of bacterial destruction by B lymphocytes.  Which way is described as destroying bacteria by coating it with antibodies to make it easier for neutrophils and tissue macrophages to phagocytize?

  • none

  • coating

  • antibody coating

  • phagocytic

  • complement system

  • none

  • coating

  • antibody coating

  • phagocytic

  • complement system

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Which term refers to molecules that activate the immune system?

  • antigen

  • exposure

  • none

  • antibody

  • immunity

  • receptor protein

  • antigen

  • exposure

  • none

  • antibody

  • immunity

  • receptor protein

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Which is mismatched with it's Latin term?

  • pain: dolor

  • edema: tumor

  • redness: dolor

  • none

  • heat: calor

  • pain: dolor

  • edema: tumor

  • redness: dolor

  • none

  • heat: calor

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Which is a cardinal sign of inflammation?

  • heat

  • loss of function

  • pain

  • edema

  • redness

  • all

  • heat

  • loss of function

  • pain

  • edema

  • redness

  • all

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Which is true about the B lymphocytes?

  • develop into plasma cells

  • secrete antibody

  • usually activated in bacterial infection

  • none

  • all are correct

  • responsible for humoral immunity

  • develop into plasma cells

  • secrete antibody

  • usually activated in bacterial infection

  • none

  • all are correct

  • responsible for humoral immunity

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Which type of WBC is an agent of the immune system?

  • neutrophils

  • lymphocytes

  • none

  • all are correct

  • monocytes

  • eosinophils

  • basophils

  • neutrophils

  • lymphocytes

  • none

  • all are correct

  • monocytes

  • eosinophils

  • basophils

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Where can you find lymphocytes?

  • lymph nodes

  • none

  • spleen

  • thymus

  • all are correct

  • lymph nodes

  • none

  • spleen

  • thymus

  • all are correct

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How many leads did you use in our in-class lab activity on ECG?

  • 12

  • 9

  • 3

  • 6

  • none

3

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Which is true about ECG?

  • none

  • the rationale behind ECG is —- body fluids has high concentration of electrolytes. The electrical activity generated by heart travels throughout the body. This activity is then monitored by placing a pair of electrodes on different areas of the skin.

  • all are true

  • it can show a + or - abnormal pattern in the heart rhythm

  • it stands for electrocardiogram

  • it is the recording of electrical events of the heart

  • none

  • the rationale behind ECG is —- body fluids has high concentration of electrolytes. The electrical activity generated by heart travels throughout the body. This activity is then monitored by placing a pair of electrodes on different areas of the skin.

  • all are true

  • it can show a + or - abnormal pattern in the heart rhythm

  • it stands for electrocardiogram

  • it is the recording of electrical events of the heart

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Which of the following is mismatched?

  • U wave: incompletely misunderstood

  • QRS complex: ventricular depolarization

  • all are mismatched

  • P wave: atrial depolarization

  • none

  • T wave: depolarization of the ventricles at the beginning of diastole

  • U wave: incompletely misunderstood

  • QRS complex: ventricular depolarization

  • all are mismatched

  • P wave: atrial depolarization

  • none

  • T wave: depolarization of the ventricles at the beginning of diastole

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Which information can be provided by ECG?

  • HR

  • cardiac hypertrophy

  • necrosis

  • ischemia

  • other conditions that may produce abnormalities of electrical conduction

  • heart rhythm

  • none

  • all are correct

  • HR

  • cardiac hypertrophy

  • necrosis

  • ischemia

  • other conditions that may produce abnormalities of electrical conduction

  • heart rhythm

  • none

  • all are correct