Campylobacter

Campylobacter spp

• s-shaped, spirally curved, gram -. pleomorphic rods,

• motile by single flagellum at one or both ends

• microaerophilic

• pathogenic and non-pathogenic

1. C.fetus

2. C.jejuni

pathogenic for animals

C. fetus

• in cattle and sheep

• Subsp. venerealis- bovine genital campylobacteriosis; abortion, metritis

• Present in genital tract and preputial cavity of asymptomatic bulls/ cows/ heifers

• may be present in semen and invade the placenta

C. jejuni

• dogs, cats, sheep, goats, calves, lab animals, mink, ferrets, chickens, turkeys

• diarrhea enterocolitis; avian infectious hepatitis

• Present in GI tract/ genital tract; spread by ingestion

subsp venerealis

• abortion may occur 5-8 months

• resorption

• placentitis

• metritis, infertility

C jejuni

• virulence factor

  • invasive (flagella and adhesin

  • cytolethal distending toxin- apoptosis

  • Enterotoxin- diarrhea

  • lipopolysaccharide- potent endotoxin

• type II and type IV secretion

• hematogenous spread

• hemorrhagoc and necrotic in liver

C. Coli

most common isolated in healthy pigs and poultry

true

true or false

Diagnosis is difficult since C. jejuni is a GI commensal, but may be seen in large numbers

gas generation packs (10 CO2. 5 O2. 85 N2)

bacterial culture isolation

1. penicillin

2. streptomycin

drugs for bovine dx

true

true or false

C.jejuni is may be self limiting; may infect companion. exotic birds and erythromycin is the tx

bacterins

can eliminate carrier state in bulls

1. Arcobacter suis

2. A.anaerophilus

• previously classified as campylobacter

• reproductive and intestinal tracts

• small, gram-, curved rods isolated in

  • diarrhea (livestock)

  • mastitis (cattle)

  • abortion (pig)

  • gastroenteritis (humans)

• isolated in feces in healthy poultry

Helicobacter pylori

• microaerophilic

• stomach and intestine of animals and humans

• inflammatory response, T cell accumulation

• gastritis and ulcer

Lawsonia intracellularis

• proliferative ileitis

• proliferative enteropathy

• in weaned pigs upto 12 weeks of age