Pharm Ana 12 - Tablets

Tablet

most common type of pill

True

T or F

The general appearance of a tablet, its identity, and general elegance is essential for consumer acceptance, for control of lot-to-lot uniformity and tablet-to-tablet uniformity.

size;
shape;
color;
presence or absence of odor;
taste & etc.

The control of general appearance involves the measurement of the following:

Size and Shape

• It can be dimensionally described & controlled.
• The thickness of a tablet is only variables.
• Tablet thickness can be measured by micrometer or by another device.
• Tablet thickness should be controlled within a ± 5% variation of standard value.

micrometer or by another device

It is used to measure tablet thickness

± 5%

Tablet thickness should be controlled within a ___% variation of standard value

1. Round
2. Square
3. Rectangle
4. Capsule
5. Almond
6. Pentagon
7. Oval
8. Lozenge
9. Diamond
10. Triangle
11. Core Rod
12. Heart

Common Tablet Shapes

Unique identification marking

• These markings utilize some form of embossing, engraving or printing.
• These markings include company name or symbol, product code, product name etc.

Convex:
1. Shallow
2. Standard
3. Deep
4. X-DEEP
5. MOD. Ball
___________________________

6. Compound Cup
7. Convex Bevel Edge
8. Flat Face Bevel Edge (FFBE)
9. Flat Face Radius Edge (FFRE)

Common Tablet Profiles

Pharmacokinetics

The principles of ADME

Absorption - How will it get in?

A in ADME

Distribution - Where will it go? Transporters

D in ADME

Metabolism - How is it broken down? Liver

M in ADME

Excretion - How does it leave?

E in ADME

Enteric coat

prevents tablet from opening in stomach at low pH (acidic)

neutral; small intestine

Enteric coat dissolves at ________ pH in the _________ (organ).

Protease inhibitor
Permeability enhancers
API

After enteric coat is dissolved in the small intestine, what substances are released?

Paracellular transport

API is absorbed acrros intestinal wall via ____________ (transport).

Peptelligence™

it orally delivers intact, biologically active API into systemic circulation

True

T or F

Efficacy has been demonstrated for peptides and small molecules varying in size, charge, hydrophobicity, stability and therapeutic indications.

Organoleptic properties

• Color distribution must be uniform with no mottling.
• For visual color comparison compare the color of sample against standard color.
• The presence of odor in a batch of tablet indicates a stability problem such as the characteristics odor of acetic acid in an aspirin tablet.
• The presence of odor could be characteristic of the drug (Vitamin), added ingredients (flavoring agent) or the dosage form (film-coated tablet have a characteristic odor).
• For chewable tablet presence or absence of specified taste can be checked.
• A tablet level of flaws such s chip, cracks, contamination from foreign solid substances (hair, drops of oil, dirt), surface texture (smooth vs rough) and appearance (shining vs dull) may have zero defect

True

T or F

Color distribution must be uniform with no mottling.

True

T or F

For visual color comparison compare the color of sample against standard color.

stability problem

The presence of odor in a batch of tablet indicates a _____________ such as the characteristics odor of acetic acid in an aspirin tablet.

drug (Vitamin);
added ingredients (flavoring agent);
or the dosage form (film-coated tablet have a characteristic odor).

The presence of odor could be characteristic of the?

True

T or F

For chewable tablet presence or absence of specified taste can be checked.

True

T or F

A tablet level of flaws such as chip, cracks, contamination from foreign solid substances (hair, drops of oil, dirt), surface texture (smooth vs rough) and appearance (shining vs dull) may have zero defect

True

T or F

Tablets will take its pharmacological effect after passing and absorbing through the small intestine.

Enteric coating

the coat gets degraded first before the API of the drug

Glomellular Filtration Rate (GFR)

is equal to the total of the filtration rates of the functioning nephrons in the kidney. GFR is considered the optimal way to measure kidney function,