Citric Acid Cycle

What compound is this?

Pyruvate

What enzyme converts pyruvate to acetyl-CoA?

Pyruvate dehydrogenase

Going from pyruvate to acetyl-CoA, what other compounds are used for the reaction?

CoASH and NAD+

What are the products of using pyruvate dehydrogenase on pyruvate?

Acetyl-CoA, CO2, NADH, and H+

What compound is this?

Acetyl-CoA

What compound is this?

Oxaloacetate

What compound is this?

Citrate

What compound is this?

Isocitrate

What compound is this?

Alpha-ketoglutarate

What compound is this?

Succinyl-CoA

What compound is this?

Succinate

What compound is this?

Fumarate

What compound is this?

Malate

What enzyme catalyzes step 1 of the citric acid cycle?

Citrate synthase

What enzyme catalyzes step 2 of the citric acid cycle?

Aconitase

What enzyme catalyzes step 3 of the citric acid cycle?

Isocitrate dehydrogenase

What enzyme catalyzes step 4 of the citric acid cycle?

Alpha-ketoglutarate dehydrogenase

What enzyme catalyzes step 5 of the citric acid cycle?

Succinyl-CoA synthetase

What enzyme catalyzes step 6 of the citric acid cycle?

Succinate dehydrogenase

What enzyme catalyzes step 7 of the citric acid cycle?

Fumarase

What enzyme catalyzes step 8 of the citric acid cycle?

Malate dehydrogenase

What are the reactants of step 1 of the citric acid cycle?

Acetyl-CoA, oxaloacetate, and H2O

What are the reactants of step 2 of the citric acid cycle?

Citrate

What are the reactants of step 3 of the citric acid cycle?

Isocitrate and NAD+

What are the reactants of step 4 of the citric acid cycle?

Alpha-ketoglutarate, CoASH, and NAD+

What are the reactants of step 5 of the citric acid cycle?

Succinyl-CoA, GDP, and Pi

What are the reactants of step 6 of the citric acid cycle?

Succinate and FAD

What are the reactants of step 7 of the citric acid cycle?

Fumarate and H2O

What are the reactants of step 8 of the citric acid cycle?

Malate and NAD+

What are the products of step 1 of the citric acid cycle?

Citrate and CoASH

What are the products of step 2 of the citric acid cycle?

Isocitrate

What are the products of step 3 of the citric acid cycle?

Alpha-ketoglutarate, CO2, NADH, and H+

What are the products of step 4 of the citric acid cycle?

Succinyl-CoA, CO2, NADH, and H+

What are the products of step 5 of the citric acid cycle?

Succinate, CoASH, and GTP

What are the products of step 6 of the citric acid cycle?

Fumarate and FADH2

What are the products of step 7 of the citric acid cycle?

Malate

What are the products of step 8 of the citric acid cycle?

Oxaloacetate, NADH, and H+

What are the rate-determining steps/enzymes of the citric acid cycle?

Step 1 (Citrate Synthase); Step 3 (Isocitrate dehydrogenase); Step 4 (Alpha-Ketoglutarate dehydrogenase)