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addiction
continued involvement with a substance or activity despite ongoing negative consequences
physiological dependence
the adaptive state of brain and body processes that occur with a regular addictive behavior and results in withdrawl
psychological dependence
dependency of the mind on a substance or behavior, which can lead to psychological withdrawl symptoms (anxiety, irritability)
biopsychosocial model of addiction
biological, psychological, and environmental factors that cause addiction
process addictions
behaviors that are known to be addictive because they’re mood altering
dopamine
neurotransmitter that relays messages about pleasure
pleasure circuit
spans the brain stem, limbic system, and the frontal region of the cerebral cortex
oral ingestion
most common - may not reach the bloodstream for as long as 30 minutes
inhalation
drugs inhaled and absorbed by the lungs - travels fastest
injection (intravenously, intramuscularly, subcutaneously)
may reach bloodstream in seconds
transdermal
absorbed through skin or tissue lining
commercial drugs
available on the market and are subject to specific requirements, including approval and labeling
over-the-counter drugs
tylenol, cold meds, zyrtec, advil
recreational drugs
taken for enjoyment - marijuana, cocaine, heroin
herbal preparations
plant-based substances that have been treated to make them suitable for therapeutic use - ginger, ginseng, garlic, tumeric
illicit drugs
illegal - either naturally occurring or prepared from natural substances - marijuana, cocaine, meth
polydrug use
use of multiple meds, vitamins, recreational, or illicit drugs
synergism
interactions of 2 or more drugs that produce more profound effects
antagonism
a type of interaction in which 2 or more drugs work at the same receptor site so that one blocks the action of another
inhibition
a drug interaction in which the effects of one drug are eliminated or reduced by another drug
intolerance
a type of interaction in which 2 or more drugs produce uncomfortable reactions
cross-tolerance
development of a tolerance to one drug that reduces the effects of another, similar drug
drugs work because
they mimic naturally produced chemicals within the body and have electrical charges and chemical structures similar to those found in the body
drug misuse
using a drug for a purpose for which it’s not intended
drug abuse
excessive use of any drug, which may cause serious harm
drugs most abused on college campuses
stimulants (adderall or ritalin) and painkillers (opiods)
opiods
compounds resembling opium in addictive properties or physiological effects
stimulants
increase heart rate, energy levels, anxiety, and depression - “uppers”
cannabis products
THC is the principle psychoactive substance in marijuana - sativa or indica
depressants
slow down neuromuscular activity and cause sleepiness and calmness - alcohol is most widely used
hallucinogens
create auditory or visual hallucinations and unusual changes in mood, thoughts, feelings, and euphoria - illegal in US
inhalents
chemicals whose vapors, when inhaled, can cause can cause hallucinations and create intoxicating and euphoric effects
anabolic steroids
ergogenic drugs used by people who believe that the drugs will increase their strength, power, bulk, speed, and athletic performance
harm reduction strategies
a set of practical approaches for reducing drug use consequences by incorporating strategies from safer drug use to abstinence
detoxification
the process of freeing a drug user from an intoxicating or addictive substance in the body or from dependence on the substance
ethanol - ethyl alcohol
the intoxicating substance in beer, wine, liquor, and liquers
fermentation
yeast organisms break down plant sugars to yield ethanol
distillation
the process by which alcohol vapors are condensed and mixed with water to make hard liquor
proof
the measure of the percentage of alcohol in the beverage
standard drink
any drink that contains about 14 grams of pure alcohol (0.6 fl oz)
alcohol is metabolized in the
liver and converted to acetaldehyde
blood alcohol concentration
ratio of alcohol to total blood volume - legal limit to drive is 0.08%
teratogenic substances
related to or causes developmental malformations in a fetus or embryo - alcohol is most dangerous
alcohol use disorder
problem drinking so severe that at least 2 or more alcohol related issues are present
tobacco
single most preventable cause of death in the US
nicotine
psychoactive ingredient in all tobacco products
tar
brownish sludge, containing various carcinogenic agents and chemical irritants
cilia
organelles on the surfaces of the lining of the upper respiratory passages that sweep away foreign material out of the airways - don’t function properly in smokers’ lungs
environmental tobacco smoke (ets)
exposure to smoke given off by tobacco products and the smoke exhaled by a smoker - firsthand and secondhand
the atria
2 upper chambers of the heart
the ventricles
2 lower chambers of the heart
heart function
heart activity depends on a complex interaction of biochemical, physical, and neurological signals
1st step of heart function
deoxygenated blood enters the right atrium after circulating through the body
2nd step of heart function
blood moves to the right ventricle and is pumped through the pulmonary artery to the lungs, where it receives oxygen
3rd step of heart function
oxygenated blood returns to the atrium of the heart
4th step of heart function
blood from the left atrium moves into the left ventricle, the left ventricle pumps blood through the aorta to all body parts
arteries
carry blood away from heart
arterioles
smaller blood vessels
capillaries
even smaller, have thin walls that permit the exchange of oxygen, carbon dioxide, nutrients, and waste products at the muscular level and within the lungs
venules
small branches of blood vessels
veins
vessels that carry blood back to the heart
sinoatrial node
located in right atrium - natural pacemaker
blood pressure
a measure of how hard blood pushes against the walls of vessels as your heart pumps
systolic bp
top number; occurs during contraction
diastolic bp
bottom number; occurs during relaxation
hypertension
a condition where the pressure in your blood vessels is consistently too high - sustained elevated bp
normal blood pressure
<120 and <80
elevated blood pressure
120-129 or <80
hypertension stage 1
130-139 or 80-89
hypertension stage 2
140 or higher or 90 or higher
hypertensive crisis
>180 or >120
arteriosclerosis
a general term for thickening and hardening of the arteries
atherosclerosis
deposits of fatty substances (plaque) on the inner lining of an artery - most common CAD
peripheral artery disease
atherosclerosis occurring in the upper and lower extremities
coronary heart disease
narrowing of the small blood vessels that supply blood to the heart
arrhythmias
an irregularity in heart rhythm that occurs when the electrical impulses in the heart that coordinate heartbeat don’t work properly
tachycardia
abnormally fast heartbeat
bradycardia
abnormally slow heartbeat
fibrillation
beats sporadically, which results in extreme inefficiency of moving blood through the body
preventricular contractions
premature heart beats in the ventricles that disrupt normal heart rhythm
angina pectoris
a symptom of CHD that occurs when not enough oxygen is supplied to the heart
cardiomyopathy
occurs when the heart is damaged or overworked, becomes enlarged, and lacks the strength to keep blood circulating normally through the body
congestive heart failure
occurs when the heart can’t pump enough blood to meet the body’s needs
diuretics
relieve fluid accumulation
digitalis
increase the pumping action of the heart
vasodilators
expand blood vessels and decrease resistence
transient ischemic attack
brief interruptions of blood supply to the brain that cause temporary impairment
ischemic stroke
caused by plaque formation that narrows a blood vessel or a clot that obstructs a blood vessel
hemorrhagic stroke
weakening of a blood vessel that causes it to bulge or rupture
aneurysm
widening or bulge in a blood vessel that may be hemorrhagic
satins
lowers blood cholesterol levels
ACE inhibitors
cause the muscles surrounding blood vessels to contract
beta-blockers
reduce blood pressure by blocking the effects of epinephrine
calcium channel blockers
prevent calcium from entering cells in heart and blood vessels; cause blood vessels to relax; allow more oxygenated blood to reach heart
metaformin
reduces the amount of sugar produced by the liver
coronary bypass
a blood vessel is taken from another site in the body and implanted to bypass the blocked coronary arteries and transport blood to heart
angioplasty
uses a thin catheter with a balloon to place a stent within a clogged artery to widen the artery
laser angioplasty and atherectomy
removes plaque within the blood vessels or arteries
metastasis
the process by which cancerous cells spread from one area to different areas of the body
carcinomas
affect epithelial tissues and are the most common