BSCI 330 Exam 1 - acetylation and methylation

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7 Terms

1
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acetylation

- decompress/compress DNA

- all or nothing process (on/off)

- neutralizes the charge on (+) lysine

2
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methylation

- decompress/compress DNA

- masks the charge

- fine tunes the attraction forces (monomethyl-, dimethyl-, trimethyl-)

- masks the charge on (+) lysine

3
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phosphorylation

turns serine into negative charge

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lysine

- positively charged amino acid; NH3+ at the end

- can regulate interactions between histones and DNA (condense, decondense)

- can modify covalently to modulate that positive charge

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serine

- polar amino acid
- can modify DNA (condense, decondense)

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acetyl lysine

- neutralized positive lysine

- (+) Lysine interacts with (-) charge elsewhere -> acetylation -> decompress DNA

- (+) Lysine interacts with (+) charge elsewhere -> acetylation -> compress DNA

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phosphoserine

- negatively charged serine

- serine interacts with (-) charge elsewhere -> phosphorylation (serine -) -> compress DNA

- serine interacts with (+) charge elsewhere -> phosphorylation (serine -) -> decompress DNA