Healing of a Skin Wound and Stratum Granulosum Events

Healing of a skin wound step #1

severed blood vessels bleed

Healing of a skin wound step #2

mast cells release histamine to dilate blood vessels and make capillaries permeable

Healing of a skin wound step #3

plasma goes into wound carrying antibodies and clotting proteins

Healing of a skin wound step #4

blood clot forms

Healing of a skin wound step #5

scab forms

Healing of a skin wound step #6

macrophages phagocytize tissue debris

Healing of a skin wound step #7

new capillaries sprout from nearby vessels

Healing of a skin wound step #8

clot is infiltrated by capillaries and fibroblasts

Healing of a skin wound step #9

tissue regenerates

Healing of a skin wound step #10

undergoes fibrosis

Healing of a skin wound step #11

maturation phase (up to 2 years)

Stratum granulosum step #1

keratohyalin granules release filaggrin (skin barrier and hydration)

Stratum granulosum step #2

cells produce tough envelope proteins beneath the membrane

Stratum granulosum step #3

membrane coating vesicles release lipid mixture to waterproof cells

Stratum granulosum step #4

keratinocytes degenerate and die