Chapter 6: Effector Mechanisms of T Cell-Mediated Immunity

Functions of T cells in Host Defense

Cell-Mediated Immunity Against Intracellular Microbes

Cell-Mediated Immunity to an Intracellular Bacterium

Cell-Mediated Immunity to an Intracellular Bacterium: Serum fails to transfer immunity

Cell-Mediated Immunity to an Intracellular Bacterium: activated macrophages kill Listeria

CD4+ Helper T Cell Subsets

Functions of TH1 cells

Activation of macrophages by TH1 lymphocytes

Cytokine-Mediated Interactions Between Lymphocytes & Macrophages in CMI

Development of TH1 Subset

TH2 Function

Development of TH2 Subset

Balance Between TH1 & TH2 Cell Activation Determines the Outcome of Intracellular Infections

Balance Between TH1 & TH2 Cell Activation Determines the Outcome of Intracellular Infections such as L. major and M. leprae

Classic and Alternative Macrophage Activation

Th17 Cell Function

Development of TH17 Subset

Mechanisms of Killing Infected Cells by CD8+ CTLs

Cooperation Between CD4+ & CD8+ T Cells

Evasion of Cell-Mediated Immunity by Microbes

Evasion of Cell-Mediated Immunity by Microbes by inhibition of antigen presentation

Evasion of Cell-Mediated Immunity by Microbes by production of cytokine or soluble receptors

T cell activation and exhaustion