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Includes questions from Mastering Biology, lecture guide, and other information that is needed to be known for EXAM II.
Two
How many fatty acids are in a phospholipid?
Negative charge to interact with water and place to attach another small charged molecule.
What functional feature(s) does the phosphate group contribute to the structure of a phospholipid?
Hydrophilic and hydrophobic interactions with water
What holds phospholipids together in a bilayer formation?
A fat molecule is less soluble in water because it has three non-polar fatty acids and no polar or charged head like a phospholipid has.
What type of molecule is less soluble in water--a fat or a phospholipid? Why?
Hydrogenated vegetable oil is solid at room temperature, whereas non-hydrogenated vegetable oil is liquid.
Hydrogenated vegetable oil is the primary ingredient in margarine. How does hydrogenated vegetable oil differ from nonhydrogenated vegetable oil?
The diverse proteins found in and attached to membranes perform many important functions.
Because membranes are fluid, membrane proteins and phospholipids can drift about in the membrane.
The framework of a membrane is a bilayer of phospholipids with their hydrophilic heads facing the aqueous environment inside and outside of the cell and their hydrophobic tails clustered in the center.
Biologists use the fluid mosaic model to describe membrane structure. What statements about the fluid mosaic structure of a membrane are correct? Select the three correct statements.
The similarity of the drug molecule to other molecules that are transported into the target cells
You are working on a team that is designing a new drug. For this drug to work, it must enter the cytoplasm of specific target cells.
What would be a factor that determines whether the molecule selectively enters the target cells?
Phosphate Group
A phospholipid has a "head" made up of a glycerol molecule attached to a single ___________________, which is attached to another small molecule.
Choline Group
Phospholipids vary in the small molecules attached to the phosphate group. The phospholipid shown in the figure has a _______________ attached to phosphate.
Hydrophilic
Because the phosphate group and its attachments are either charged or polar, the phospholipid head is _______________, which means it has an affinity for water.
Fatty Acid
A phospholipid also has two "tails" made up of two _______________ molecules, which consist of a carboxyl group with a long hydrocarbon chain attached.
Hydrophobic
Because the C-H bonds in the fatty acid tails are relatively non-polar, the phospholipid tails are _______________, which means they are excluded from water.
Non-Polar molecules
Ex: Hydrocarbons, O2, & CO2
Hydrophobic, can cross easily, & no transport protein required.
Polar molecules
Ex: Water & Sugars
Hydrophilic, have difficulty crossing the hydrophobic part, and requires a transport protein to cross.
Ions
Ex: Na+, Ka+, Ca2+, & Cl-
Hydrophilic, have difficulty crossing the hydrophobic part, and requires a transport protein to cross.
Always
Orange dye moves independently of purple dye. When is this true?
Only before equilibrium is reached
Concentration gradients exist that drive diffusion of both dyes. When is this true?
Only before equilibrium is reached
There is a net movement of orange dye from Side A to Side B. When is this true?
Never
Purple dye moves only from Side B to Side A. When is this true?
Only at equilibrium.
There is no net movement of purple dye. When is this true?
Primary Structure
Which protein structure cannot be easily broken?
CO2, O2, water, & lipids
What molecules can cross the lipid bilayer of a membrane directly, without a transport protein or other mechanism?
Channels
What type transport protein allows water molecules & small ions to flow quickly across the membrane, and provide a continuous path across the membrane?
Carriers
What type of transport protein primarily transports small polar organic molecules, and undergoes a change in shape to transport solutes across the membrane?
3 Na+
How much sodium is released in a Sodium Potassium pump?
2 K+
How much potassium is pumped in a Sodium Potassium pump?
The diffusion of Na+ ions into the cell is facilitated by the Na+ concentration gradient across the plasma membrane.
The diffusion of K+ ions out of the cell is impeded by the electrical gradient across the plasma membrane.
The electrochemical gradient is larger for Na+ than for K+.
What are the driving forces for diffusion of Na+ and K+ ions through their respective channels?
Secretes large molecules out of the cell.
Increases the surface area of the plasma membrane.
Requires fusion of vesicles with the plasma membrane.
What describes Exocytosis?
Forms vesicles from inward folding of the plasma membrane.
Decreases the surface area of the plasma membrane.
What describes Endocytosis?
Transported substances never physically cross the plasma membrane.
Requires cellular energy.
How are Exocytosis and Endocytosis similar?
Water flows into the cell to the same extent that it flows out of the cell.
What happens in an isotonic solution?
Water flows into the cell, which causes it to swell and potentially burst (lyse).
What happens in a hypotonic solution?
Water flows out of the cell, which causes it to shrink.
What happens in a hypertonic solution?
True
With the Sodium potassium, the sodium and potassium ions are transported against their concentration gradients.
True or False?
into ... membranous vesicles
Endocytosis moves materials _____ a cell via _____.
The cell is engulfing extracellular fluid.
You can recognize the process of pinocytosis when _____.
Phagocytosis
A white blood cell engulfing a bacterium is an example of _____.
The cell engulfs a large particle.
What happens in phagocytosis?
“Cell Drinking”
Pinocytosis is also known as what?
Inward
What does the prefix “endo” mean?
Dehydration
What is another name for a condensation reaction?
Hydrolysis
What is the name of the process during which a bond between two monomers is broken?
Amino Acid
Protein polymers are made up of _______________ monomers.
Nucleotide
Nucleic acid polymers are made up of _____________ monomers.
Simple Sugar
Carbohydrate polymers are made up of ______________ monomers.
Structural
Arrow A is indicating a(n) _____ protein.
Receptor
Arrow D is indicating a _____ protein.
Ovalbumin
Which of these does NOT contain a structural protein?
a) Ligaments
b) Ovalbumin
c) Spider Silk
d) Muscles
e) Tendons
Immune
Defensive proteins are manufactured by the _____ system.
Amino Acids
Proteins are polymers of _____.
Peptide
What type of bond joins the monomers in a protein's primary structure?
Hydrogen Bonds
The secondary structure of a protein results from _____.
Peptide Bonds
Tertiary structure is NOT directly dependent on _____.
Tertiary
____________ structure is achieved when a protein folds into a compact, three-dimensional shape stabilized by interactions between side-chain R groups of amino acids.
Quaternary
________________ structure is the result of two or more protein subunits assembling to form a larger, biologically active protein complex.
Secondary
______________ structure describes the alpha-helices and beta-sheets that are formed by hydrogen bonding between backbone atoms located near each other in the polypeptide chain.
Primary
___________ structure is the sequence of amino acids in a protein.
True
The primary structure of a protein is the order of amino acids in a polypeptide, as coded for in the DNA of a gene.
True or False?
The new amino acid would not form the same interactions with hydrophobic R groups, and the protein's shape would likely be affected.
What could happen if a mutation in a gene caused a hydrophobic amino acid in a polypeptide to be replaced by a hydrophilic amino acid?
Alzheimer’s is a neurological disease with loss of memory and motor skills.
What statement best describes Alzheimer’s disease?
True
There is a correlation between beta-amyloid plaques and the severity of Alzheimer’s disease.
True or False?
Region C
Look at the graph of reaction rate versus substrate concentration for an enzyme.
In which region does the reaction rate remain constant?
Region C
Refer again to the graph.
In which region is the enzyme saturated with substrate?
Increase the substrate concentration.
Consider a situation in which the enzyme is operating at optimum temperature and pHpH, and has been saturated with substrate. What is your best option for increasing the rate of the reaction?
Competitive
A _______________ inhibitor has a structure that is so similar to the substrate that it can bond to the enzyme just like the substrate.
Non-Competitive
A _________________ inhibitor binds to a site on the enzyme that is not the active site.
Irreversible
Usually a(n) ________________ inhibitor forms a covalent bond with an amino acid side group within the active site, which prevents the substrate from entering the active site or prevents catalytic activity.
Active Site
The competitive inhibitor competes with the substrate for the ______________ on the enzyme.
Shape
When the noncompetitive inhibitor is bonded to the enzyme, the ___________ of the enzyme is distorted.
Substrate
Enzyme inhibitors disrupt normal interactions between an enzyme and its ___________.
The enzyme is inactive at this point. New enzyme must be added to regain enzyme activity.
You have added an irreversible inhibitor to a sample of enzyme and substrate. At this point, the reaction has stopped completely.
What can you do to regain the activity of the enzyme?
Add more substrate; it will outcompete the inhibitor and increase the reaction rate.
You have an enzymatic reaction proceeding at the optimum pH and optimum temperature. You add a competitive inhibitor to the reaction and notice that the reaction slows down.
What can you do to speed the reaction up again?
Denatured
An enzyme is _____________ when it loses its native conformation and its biological activity.
Catalyst
An enzyme is considered a __________ because it speeds up chemical reactions without being used up.
Specific
An enzyme is considered __________ because of its ability to recognize the shape of a particular molecule.
Cofactor
A ___________, such as a vitamin, binds to an enzyme and plays a role in catalysis.
Complex
When properly aligned, the enzyme and substrate form an enzyme-substrate (ES) ___________.
Active Site
A substrate binds to an enzyme at the ______________, where the reaction occurs.
Substrate
In a catalyzed reaction a reactant is often called a ___________.
A similar shape exists between a pocket on the surface of the enzyme and a functional group on the substrate.
What would unlikely to contribute to the substrate specificity of an enzyme?
increase the rate of a reaction without being consumed by the reaction
Enzymes are described as catalysts, which means that they __________.
The compound is a competitive inhibitor.
The binding of a compound to an enzyme is observed to slow down or stop the rate of the reaction catalyzed by the enzyme. Increasing the substrate concentration reduces the inhibitory effects of this compound. What could account for this observation?
Plasma Membrane
What cell structure allows selective permeability between a cell and its external environment?
True
Phospholipids form a selectively permeable structure.
True or False?
True
The fluid aspect of the membrane is due to the lateral and rotational movement of phospholipids, and embedded proteins account for the mosaic aspect.
True or False?
Wedged between phospholipid molecules in the interior of the membrane
Under the fluid mosaic model, where in the plasma membrane would cholesterol most likely be found?
Energy, carbon, and nitrogen storage
What functional process is not a consequence of the association of proteins with biological membranes?
True
Membrane carbohydrates function primarily in cell-cell recognition. True or False?
On the outside (external) surface of the membrane
Where in the fluid mosaic model of the membrane would carbohydrates be found?
Carbon Dioxide
Explanation: Hydrophobic molecules, such as hydrocarbons, carbon dioxide, and oxygen, can dissolve in the membrane and cross it with ease.
Which molecule is most likely to passively diffuse across the plasma membrane?
a) Carbon Dioxide
b) Hemoglobin
c) Glucose
d) DNA
e) Sodium Ion
A large polar molecule
Which would be least likely to diffuse through a plasma membrane without the help of a transport protein?
a) Dissolved gases such as oxygen or carbon dioxide
b) A large polar molecule
c) A large nonpolar molecule
d) A small nonpolar molecule
e) All choices are correct
Proteins embedded in two layers of phospholipid
Explanation: With the proteins embedded within two layers of phospholipids, the cell retains its general restriction on the unregulated movement of polar molecules across the membrane, and the proteins provide for selective transport functions.
What structural arrangement of the components in biological membranes is most consistent with membrane’s property of selective permeability?
True
Passive transport permits the solute to move in either direction, but the net movement of the population of solute occurs down the concentration gradient of the molecule.
True or False?
B … the diffusion gradient in cell B is steeper.
Explanation: As long as a metabolically active cell converts oxygen to water during cellular respiration shortly after it enters, diffusion into the cell will continue because the concentration gradient favors movement in that direction.
Cells A and B are the same size, shape, and temperature, but cell A is metabolically less active than cell B; cell B is actively converting oxygen to water in cellular respiration. Oxygen will diffuse more rapidly into cell __________ because __________.
True
Diffusion is a passive process of a substance across a membrane with no energy investment.
True or False?
1.0 M
Explanation: This is hypertonic to the plant cell. Water will leave the cell, and eventually the plasma membrane will pull away from the cell wall, resulting in plasmolysis.
The internal solute concentration of a plant cell is about 0.8 M. To demonstrate plasmolysis, it would be necessary to suspend the cell in what total concentration of solutes?
Water would leave the cell by osmosis, causing the volume of the cytoplasm to decrease.
Explanation: The added salt makes the solution hypertonic compared to the cell. Water will leave the cell by osmosis.
A single plant cell is placed in an isotonic solution. Salt is then added to the solution. Which would occur fairly quickly as a result of that addition?
Facilitated diffusion of solutes may occur through channel or transport proteins in the membrane.
What describes some aspect of facilitated diffusion?
False
Explanation: Facilitated diffusion, like passive diffusion, needs only a concentration gradient--no energy input is required.
Facilitated diffusion requires the hydrolysis of ATP.
True or False?
A hypertonic sucrose solution
Explanation: When a cell is placed in a hypertonic environment, water will leave the cell, causing it to shrink.
The red blood cell contain about 2% solutes but almost no sucrose or urea. Sucrose cannot pass through the membrane, but water and urea can. Osmosis would cause red blood cells to shrink most when immersed in what type of solution?
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