Pharm Exam 1 Concept: Pharmacokinetics

4 phases of pharmacokinetics

1. Absorption

2. Distribution

3. Metabolism

4. Excretion

Definition of Pharmacokinetics

the study of what happens to a drug from the time its put into the body until the parent drug and all metabolites have left the body.

Definition of Absorption

Movement of a drug from the site of administration into the bloodstream for distribution

Routes of drug administration

Enteral

Parenteral

Topical

Inhalation

Ocular

Otic

Definition of Distribution

transport of a drug by the blood stream to the site of action. it depends on blood flow, affinity to the body tissues, and protein-binding affect.

What happens if a patient takes highly protein bound medication and has low serum albumin?

Patient is at greater risk for toxicity.

What is the blood brain barrier

drug molecules need to be lipophilic or transport system to pass to the other side

What is the blood placenta barrier

Drug must be lipophilic, noniodized, and not protein bound

Definition of Metabolism

sequence of chemical events that change a drug after it enters the body

What is the principal site of metabolism?

The liver

Definition of excretion

process by which the drugs are eliminated from the body

Where can drugs excrete from in the body

Kidneys #1

(also intestines, lungs, mammary glands, sweat glands, and salivary glands)