Unit 2.1. Introduction to Autonomic Nervous System

Central and Autonomic Nervous System

The Nervous System is composed of:

Brain and Spinal Cord

The Central Nervous System is composed of:

Nerves, Bundled Axons, and Neurons in the Visceral Organs

The Autonomic Nervous System is composed of:

Autonomic Nervous System

responsible for the moment-to-moment regulation of the internal environment (e.g., sweating, respiration, secretions, metabolism, & body temperature)

Sympathetic and Parasympathetic Nervous System

Autonomic Nervous System is divided into:

Adrenergic

Sympathetic NS is also known as:

Cholinergic

Parasympathetic NS is also known as:

Fight or Flight Response

Sympathetic NS is responsible for:

Rest and Digest Response

Parasympathetic NS is responsible for:

short

Sympathetic NS has a:

a. _____ pre-ganglionic

b. _____ post-ganglionic

a = ?

long

Sympathetic NS has a:

a. _____ pre-ganglionic

b. _____ post-ganglionic

b = ?

long

Parasympathetic NS has a:

a. _____ pre-ganglionic

b. _____ post-ganglionic

a = ?

short

Parasympathetic NS has a:

a. _____ pre-ganglionic

b. _____ post-ganglionic

b = ?

thoracolumbar (T1-12 & L1-5)

Sympathetic NS is located in:

craniosacral (CN3,7,9,10, S-4)

Parasympathetic NS is located in:

Acetylcholine

ANS PHYSIOLOGY PROCESS:

a. ___________________ are released in the pre-ganglion of both sympathetic and parasympathetic NS.

b. This neurotransmitter are received by the receptors on the ganglion known as ___________ receptors.

c.1. For the parasympathetic NS, the Neurotransmitter released on the post-ganglion was ______________ while the receptor is _____________________.

c.2. For the sympathetic NS, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.3. EXEMPTIONS IN THE SYMPATHETIC NS: For sweat glands, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.4. EXEMPTIONS IN THE SYMPATHETIC NS: For renal vascular smooth muscle, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

a = ?

Nicotinic

ANS PHYSIOLOGY PROCESS:

a. ___________________ are released in the pre-ganglion of both sympathetic and parasympathetic NS.

b. This neurotransmitter are received by the receptors on the ganglion known as ___________ receptors.

c.1. For the parasympathetic NS, the Neurotransmitter released on the post-ganglion was ______________ while the receptor is _____________________.

c.2. For the sympathetic NS, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.3. EXEMPTIONS IN THE SYMPATHETIC NS: For sweat glands, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.4. EXEMPTIONS IN THE SYMPATHETIC NS: For renal vascular smooth muscle, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

b = ?

Acetylcholine; Muscarinic

ANS PHYSIOLOGY PROCESS:

a. ___________________ are released in the pre-ganglion of both sympathetic and parasympathetic NS.

b. This neurotransmitter are received by the receptors on the ganglion known as ___________ receptors.

c.1. For the parasympathetic NS, the Neurotransmitter released on the post-ganglion was ______________ while the receptor is _____________________.

c.2. For the sympathetic NS, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.3. EXEMPTIONS IN THE SYMPATHETIC NS: For sweat glands, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.4. EXEMPTIONS IN THE SYMPATHETIC NS: For renal vascular smooth muscle, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.1. = ?

Norepinephrine; alpha and beta

ANS PHYSIOLOGY PROCESS:

a. ___________________ are released in the pre-ganglion of both sympathetic and parasympathetic NS.

b. This neurotransmitter are received by the receptors on the ganglion known as ___________ receptors.

c.1. For the parasympathetic NS, the Neurotransmitter released on the post-ganglion was ______________ while the receptor is _____________________.

c.2. For the sympathetic NS, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.3. EXEMPTIONS IN THE SYMPATHETIC NS: For sweat glands, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.4. EXEMPTIONS IN THE SYMPATHETIC NS: For renal vascular smooth muscle, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.2. = ?

Acetylcholine; Muscarinic

ANS PHYSIOLOGY PROCESS:

a. ___________________ are released in the pre-ganglion of both sympathetic and parasympathetic NS.

b. This neurotransmitter are received by the receptors on the ganglion known as ___________ receptors.

c.1. For the parasympathetic NS, the Neurotransmitter released on the post-ganglion was ______________ while the receptor is _____________________.

c.2. For the sympathetic NS, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.3. EXEMPTIONS IN THE SYMPATHETIC NS: For sweat glands, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.4. EXEMPTIONS IN THE SYMPATHETIC NS: For renal vascular smooth muscle, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.3. = ?

dopamine; dopamine

ANS PHYSIOLOGY PROCESS:

a. ___________________ are released in the pre-ganglion of both sympathetic and parasympathetic NS.

b. This neurotransmitter are received by the receptors on the ganglion known as ___________ receptors.

c.1. For the parasympathetic NS, the Neurotransmitter released on the post-ganglion was ______________ while the receptor is _____________________.

c.2. For the sympathetic NS, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.3. EXEMPTIONS IN THE SYMPATHETIC NS: For sweat glands, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.4. EXEMPTIONS IN THE SYMPATHETIC NS: For renal vascular smooth muscle, the neurotransmitter released on the post-ganglion was ________________ while the receptor is _____________________.

c.4. = ?

Gq

G-PROTEINS:

a. produces phospholipase leads to an increase in IP3 & DAG

b. produces adenylate cyclase leads to a decrease in cAMP

c. produces adenylate cyclase leads to an increase in cAMP

a = ?

Gi

G-PROTEINS:

a. produces phospholipase leads to an increase in IP3 & DAG

b. produces adenylate cyclase leads to a decrease in cAMP

c. produces adenylate cyclase leads to an increase in cAMP

b = ?

Gs

G-PROTEINS:

a. produces phospholipase leads to an increase in IP3 & DAG

b. produces adenylate cyclase leads to a decrease in cAMP

c. produces adenylate cyclase leads to an increase in cAMP

c = ?

nerve endings (CNS)

MUSCARINIC RECEPTORS (PARASYMPATHETIC or CHOLINERGIC):

M1

Location: ?

G-protein:

Gq

MUSCARINIC RECEPTORS (PARASYMPATHETIC or CHOLINERGIC):

M1

Location:

G-protein: ?

heart (CS)

MUSCARINIC RECEPTORS (PARASYMPATHETIC or CHOLINERGIC):

M2

Location: ?

G-protein:

Gi

MUSCARINIC RECEPTORS (PARASYMPATHETIC or CHOLINERGIC):

M2

Location:

G-protein: ?

smooth muscles, glands, endothelium (GIT, glands)

MUSCARINIC RECEPTORS (PARASYMPATHETIC or CHOLINERGIC):

M3

Location: ?

G-protein:

Gq

MUSCARINIC RECEPTORS (PARASYMPATHETIC or CHOLINERGIC):

M3

Location:

G-protein: ?

effector tissues: peripheral blood vessels, bladder, and eyes

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

a-1

Location: ?

G-protein:

Gq

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

a-1

Location:

G-protein: ?

peripheral blood vessels, CNS

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

a-2

Location: ?

G-protein:

Gi

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

a-2

Location:

G-protein: ?

heart

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

b-1

Location: ?

G-protein:

Gs

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

b-1

Location:

G-protein: ?

lungs, uterus, smooth skeletal muscles

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

b-2

Location: ?

G-protein:

Gs

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

b-2

Location:

G-protein: ?

Adipose Tissue

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

b-3

Location: ?

G-protein:

Gs

ALPHA & BETA RECEPTORS (SYMPATHETIC or ADRENERGIC)

b-3

Location:

G-protein: ?