BIS2A Mutations

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Last updated 8:25 PM on 1/10/26
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6 Terms

1
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Direct chemical reversal

  • damaged bases

  • most energy efficient

    • no excision of DNA backbone

2
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MMR (mismatch repairs)

  • mismatch in replication

  • excision of DNA backbone

    • proteins are able to recognize that base is paired incorrecctly

    • cuts out base and some adjacent which creates gap

    • DNA polymerase 1 then adds correct bases

    • DNA ligase repairs the remaining nicks

3
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BER (base excision repair)

  • damaged bases

  • excision of DNA backbone

  • AP site

4
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NER (nucleotide excision repair)

  • damaged bases

  • excision of DNA backbone

  • thymine dimer

5
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Exonuclease

  • nucleus can cut the end of the chromosome

6
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endonuclease

  • chromosome is cut in the middle