Blood and Marrow Transplantation

cellular therapy, HCT/HSCT/SCT/BMT, adoptive cell therapy definitions

normal hematopoiesis

types of HCT

auto- v. allo-HCT

auto HCT steps

allo HCT steps

auto HCT common indications- malignant, non-malignant

allo HCT common indications

indications for HCT

pre-HCT assessment

mobilization strategies

donor selection- HLA matching

a “clinical match”

likelihood of finding 8/8 HLA match donor

donor selection algorithm for allogeneic HCT

conditioning/preparative regimens

complications post-HCT

complications post-HCT

risk factors, infectious, non-infectious

supportive care- anti-microbial prophylaxis

supportive care

immunizations

allogeneic HCT- specific complications

GvHD and GvT responses

GvHD

pathogenesis of GvHD

GvHD syndromes after alloHCT

basic therapy of acute and cGVHD

graft failure, rejection

types of graft rejection in transplantation

causes of death following autoHCT

IEC immunotherapy

CAR-T therapy

chimeric antigen receptor design

building a CAR

CAR T cells- MOA

overview of CAR T therapy

current IECT indications

FDA approved CAR-T cell therapies

CAR-T therapy toxicities

typical onset and resolution of CRS and neurologic events

therapy for sickle cell disease

gene therapy for hemoglobinopathies

FDA approved gene therapies for SCD and B Thal