HEMA LEC - WEEK 4 (SECONDARY HEMOSTASIS)

coagulation

a process whereby, on vessel injury, plasma proteins, tissue factors, and calcium interact on the surface of platelets to form a stable fibrin clot.

Platelets

______ also interact with fibrin to form a stable platelet-fibrin clot.

zymogen

involving development of enzymes from their precursors

serine protease

activated

zymogen

inactivated

clot

end product

secondary hemostasis

Involves the enzymatic activation of series of plasma proteins in the coagulation system to form a fibrin meshwork

fibrin meshwork

secondary hemostasis involves the enzymatic activation of series of plasma proteins in the coagulation system to form a ______

fibrin meshwork

supports platelet plug

step 4 and 5

step __ and __ are involved in secondary hemostasis

Fibrin-Platelet plug formation

step 4

fibrin stabilization

step 5

factor XIII

fibrin clot must be stabilized by coagulation ____

fibrin

Coagulation factors interact on platelet surface to produce ______

fibrinogen

factor I name

prothrombin

factor II name

tissue factor

factor III name

calcium

factor IV name

proaccelerin

factor V name

-Proconvertin

—Stable factor

-Serum prothrombin conversion accelerator (SPCA)

factor VII name (3)

-antihemophilic factor (AHF)

-antihemophilic factor A

factor VIII name

-plasma thromboplastin component

-antihemophilic factor B

-christmas factor

factor IX name (3)

-stuart-prower factor

-prower factor

-stuart factor

factor X name

-plasma thromboplastin antecedent (PTA)

-antihemophilic factor C

factor XI name

-hageman factor

-glass factor

-contact factor

factor XII name (3)

-fibrin stabilizing factor

-laki-lorand factor

factor XIII name (2)

fletcher factor

other name for prekallikrein

fitzgerald factor

williams factor

flaujeac factor

other name for high molecular weight kininogen (3)

1. substrate

2. cofactors

2 categories of coagulation factors

cofactors

assistt in activation of zymogen

factor 12, 11, PK, HMWK

contact group

factor 12, 11, PK, HMWK

factors not assist bleeding

factor 2, 7, 9, 10 (1972)

prothrombin/vitamin k dependent group

factor 1, 5, 8, 13

fibrinogen group

fibrinogen group

what group is found in alpha group except factor 13

platelet cytoplasm

factor 13 is found in ________

contact and prothrombin group

found in serum and plasma

fibrinogen group

found in plasma

roman numeral

inactive form is written as _______

letter "a"

active forms are usually designated by the letter:

cofactors

needed for many reactions in the cascade

liver

factor 13 is synthesized in:

factor 13

stabilizes the linkage between the fibrin monomers of the blood clot

plasma

platelets

factor 13 is present in (2):

150 hours

half life of factor 13

factor 13

it will help the fibrin to stabilize the fibrin clot

factor 12

hageman factor

48-70 hours

half life of hageman factor (12)

factor 12 (hageman)

this factor is activated by contact with foreign surfaces, and initiates the intrinsic system

factor 12 (hageman)

involved in the activation of the fibrinolysis

factor 11 and 11a

factor 12 will activate (2):

factor 11

-a serine protease beta or gamma globulin partly consumed in clotting

-found in serum and plasma

48-84 hours

factor 11 half life:

factor 10

-serine protease not consumed in the clotting process

-found in both serum and plasma

factor 10

activated by extrinsic and intrinsic

48-52 hours

half life of factor 10

factor II (prothrombin)

once factor 10 is activated it will react with calcium, FVIIIa, PL, and activate ________

thrombin

once factor II is activated, it will become ______

fibrin

thrombin activates fibrinogen to become _________

stable fibrin clot

fibrin forms ______ together with factor 13a

factor 9

-present in serum and plasma

-vitamin k dependent

-not consumed during clottting

24 hrs

half life of factor 9

factor 9

activated by factor 10a with calcium

factor 8

antihemophilic factor A

thrombin

actiator of factor 8

endothelium lining blood vessel and platelet

source of factor 8

-works with factor 9 and calcium

-activate factor 10

actions of factor 8

hemophilia A

deficiency of factor 8 will lead to:

extrinsic pathway

shortest pathway

factor 7

stable factor

factor 7

activated by tissue thromboplastin

6 hours

half life of factor 7

factor 7 (6 hrs)

shortest half life

factor 7a

___ works with tissue factor and calcium to activate factor 10

factor 5

unstable when stored in citrated plasma

factor 5

-consumed in clotting

-not found in serum

24 hrs

half life of factor 5

1mg/dl

mean platelet count of factor 5

factor 4

active form of calcium

8-10mg/dl

mean platelet count of factor 4

factor 3

tissue factor

thromboplastin

required for the conversion of prothrombin to thrombin

factor 2

-proenzyme

-precursor of thrombin

10-20mg/dl

mean platelet count of factor 2

60 hours

half life of factor 2

factor 2

activated by factor 10a

factor 1

substrate for thrombin and precursor of fibrin

factor 1

fibrinogen

hypofibrinogenemia

low fibrin

afibrinogenemia

no fibrin

dysfibrinogenemia

decreased fibrin

100-150hours

half life of factor 1

prekallikrein

plasma protein with a molecular weight of 85,000 daltons

absorbed barium sulfate

not absorbed by aluminum hydroxide

prekallikrein is absorbed by _______ and not absorbed by _________

prekallikrein

activator of factor 11 in conjunction with HMWK

35 hrs

half life of prekallikrein

high molecular weight kininogen

activator of factor 11 in effect with prekallikrein

1. extrinsic

2. intrinsic

3. common

3 pathways of coagulation

intrinsic pathway

-occurs when vessel is injured

-exposing subendothelial basement membrane and collagen

intrinsic pathway

lead to activation of contact factor