Transcription factors in B-cell activation
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Which transcription factors promote B-cell proliferation and differentiation?
NFAT, NF-κB, and AP-1 promote B-cell proliferation and differentiation.
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What happens to some B cells after activation?
Some B cells differentiate into plasma cells that begin to produce soluble IgM.
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What do other B cells do after activation?
Other B cells migrate to a lymphoid follicle, form a germinal center, undergo affinity maturation, or become memory cells.
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