120.4

Which systems are most often associated with IgM antibodies? IgG antibodies?

IgG: duffy, kidd, kell,IgM: Lutheran, Lewis, I

Which immunoglobulin class of antibodies would cause agglutination at room temperature that disperses at 37°C?

IgM

To produce Leb antigens on the red cells. Which gene must be inherited?

The Le Se and H must be present

What Lewis phenotype do all newborns have?

NONE; not intrinsic to the RBC membrane, Lewis are not alleles, got to have the H to turn the Lea to Leb, secretor gene lets the H antigen act

Which antibodies are enhanced by lowering the pH to 6.5?

Anti M and N

Which part of the Black population can form anti-U antibody?

S s persons

Which persons can produce P1 antibody?

P2

Which blood group system is associated with PCH?

P blood group

Which antibody is associated with increased incidence of spontaneous abortion?

Anti-P1 and anti- PP1P^k

List the substances that will neutralize anti-P1 antibodies.

hydatid cystic fluid

Which three blood group systems exhibit linkage?

Lewis, Lutheran,MNS

Which infections are associated with the presence of these antibodies in the patient's serum? Anti I

Mycoplamsa pneumoniae, cold hemagglutinin disease

Which infections are associated with the presence of these antibodies in the patient's serum? Anti i

infectious mono, lymphoproliferative disease, cold hemagglutinin disease (occasionally)

What I/i phenotype do all babies have at birth?

j antigen

Which blood group antibody is seen most often other than Rh antibodies?

kell

Which blood group antigens are destroyed by sulfhydryl compounds?

kell

Which Kell antigens are seen in high frequency in Blacks?

K-k+, Kp(a-b+)

Which Kell antigens are seen in the white population?

K-k+, Kp (a+b-)

Which disease is associated with McCleod phenotype?

chronic granulomatous disease

Is protection against malaria associated with which genotype usually seen in Blacks?

The Fy(a-b-) phenotype is found frequently in people from west and central Africa, supporting the theory of selective evolution

Which two blood group systems are associated with delayed HTR?

Kidd ( most often), Duffy

Which blood group antibodies exhibit dosage?

Duffy, Kidd, MNS

Which blood group antigens are destroyed by enzyme enhancement?

Duffy

Which blood group antigens are enhanced by enzyme enhancement?

Kidd

What is the function of rabbit red cells stroma in testing procedures?

To remove cold autoantibodies from patient samples to facilitate the detection of underlying alloantibodies

Which blood group is seen primary in native South Americans and Asians?

Diego

What is the purpose of the prewarming technique?

to get rid of cold agglutination

If any antibody is identified in recipient serum, what must be done before they are given red blood cells?

They would need to be cross matched so that they don't get the corresponding antigen to their antibody

What are low frequency antigens?

1%, not as common

High frequency antigens?

99%, more common

Give an example of-
Low frequency antigen

Cw, V, Kpa, Jsa, Lua, Mg, Vw, Dia, Wra, Cob

Give an example of-
High frequency antigen-

Kpb, k, Jsb, Lub, I, Ge, Tja, Vel, Yta, Dib, Coa, and U

Which are the most common HTLA antibodies?

anti-Ch, Rg, JMH, Csa, Kna, McCa and Yka

Describe the purpose of HLA testing in platelet transfusion?

They determine if they have any antibodies that would target the donor's platelets and prevent a good response to the transfusion

Which HLA antigen is found in red blood cells?

Bg antigens (HLA class 1)

Which of the following facts is not a characteristic of Kell system antibodies?

Lose reactivity with proteolytic enzyme reagents

Which condition is often associated with the presence of anti-I?

Mycoplasma pneumoniae infection

Antigens of the P system are structurally related to which of the following blood group systems?

ABH

The Donath-Landsteiner antibody is:

an IgG auto anti-P.

Red cells that phenotype as S–s– are also:

U-negative

The following statements regarding anti-P1 are true except:

anti-P1 will not react with enzyme-treated P1 positive red cells.

Kidd

Antibodies may fall below detectable levels and associated with delayed transfusion reactions.

High frequency antigen

Kp^b

If all red cells tested at room temperature are positive with a patient's serum except for cord cells, the probably antibody identity is:

anti-I.

A person who inherits the Le, Se, and H genes will have red cells that phenotype:

Le(a–b+).

Lewis system antibodies have not been implicated in hemolytic disease of the fetus and newborn because:

all of the above are correct.

Antibodies to Lu^b antigen are not commonly detected because:

Lu^b antigen is of high incidence.

Antibodies to which of the following blood group system show dosage (i.e., are stronger with homozygous expression of the antigen)?

Duffy

Which of the following phenotypes is heterozygous?

Fy(a+b+)

Antibodies to Kidd, Kell, and Duffy blood group antigens share all the following characteristics except:

enhanced with enzyme treatment

Associated with chronic granulomatous disease

K_x

System associated with glycophorin A and B

MNSs

with resistance to malaria

Duffy

Which of these antibodies does NOT demonstrate dosage effect?

Anti-Le^a and Anti-Le^b

Le^a and Le^b are alleles in the Lewis Blood System.

False