Virology: Hepatitis Viruses

studied byStudied by 24 people
5.0(2)
get a hint
hint

Hepatitis

1 / 50

Tags and Description

51 Terms

1

Hepatitis

inflammation of the liver -results in jaundice -results in elevated levels of serum alanine aminotransferase levels (ALT)

New cards
2

Hepatitis: non-infectious causes

bacterial, fungal, parasites

New cards
3

Hepatitis: viral

hepatitis virus yellow fever virus some herpes virus

New cards
4

Hepatitis: types

A, B, C, D, E, & G Predominant types: A, B, C all have acute infections Chronic infections: B, C, G

New cards
5

Hepatitis A: characteristics

+ss RNA virus naked (non-enveloped) human & primate hosts -restricted to humans though

New cards
6

Hepatitis A: Transmission

fecal-oral: restaurants and frozen foods -GI tract --> blood --> liver -can also be found in other tissues (issue for organ transplants)

New cards
7

Hepatitis A: Disease

acute infection only Incubation: 10-50 days -starts w/ flu-like symptoms -dose dependent (higher does --> earlier onset) age effect

New cards
8

Hepatitis A: Age Effect

Children: -subclinical infection (no disease)- 80-95% -clinical infection (disease)- 5-20% -recovery- 99%

Adult -subclinical infection (no disease)- 10-25% -clinical infection (disease)- 75-90% -recovery- 99%

New cards
9

Hepatitis A: treatment

drugs: none

New cards
10

Hepatitis A: vaccine

whole inactivated --> standard for children -previously only given to people traveling to endemic areas

New cards
11

Hepatitis A: passive immunization

works!

New cards
12

Hepatitis A: Prevention

vaccination, good hygiene, sanitation, clean needles

New cards
13

Hepatitis E: characteristics

originally thought to be Hep A +ss RNA virus Naked (non-enveloped) human, primate, and swine hosts

New cards
14

Hepatitis E: transmission

fecal-oral

New cards
15

Hepatitis E: disease

acute infection only Incubation: 10-50 days -starts w/ flu-like symptoms -dose dependent (higher dose-->earlier onset) no age effect Disease a bit more severe than Hep A dangerous to pregnant women (mortality increase as pregnancy progresses)

New cards
16

Hepatitis E: passive immunization

does NOT work

New cards
17

Hepatitis E: vaccine

none

New cards
18

Hepatitis E: treatment

drugs: none

New cards
19

Hepatitis E: prevention

good hygiene, sanitation, cook pork

New cards
20

Hepatitis G: characteristics

aka GBV-C 15% of population is positive (seropositive) +ss RNA virus enveloped same viral family as Hep C human host -infects hepatocytes and lymphocytes -alters HIV infection (decrease HIV replication)

New cards
21

Hepatitis G: transmission

bodily fluids: sex, blood

New cards
22

Hepatitis G: disease

acute and chronic infections no age effect

New cards
23

Hepatitis G: passive immunization

does NOT work

New cards
24

Hepatitis G: vaccine

none

New cards
25

Hepatitis G: treatment

drugs: none

New cards
26

Hepatitis G: prevention

safe sex, clean needles

New cards
27

Hepatitis B: characteristics

ds DNA virus (pseudo retrovirus) enveloped human host

New cards
28

Hepatitis B: transmission

bodily fluids: sex, blood, birth -transmissibility related to viremia levels (viral load) -10% chronically infected mothers will pass it on to their children

New cards
29

Hepatitis B: disease

acute and chronic infections Incubation: 45-160 days Age effect chronic infection: reactivation (carrier state) -latency

New cards
30

Hepatitis B: age effect

Newborns: -acute: 5-10% -chronic: 90-95%

Adults: -acute: 90-95% -chronic: 5-10%

New cards
31

Hepatitis B: chronic disease

cirrhosis, hepatocellular carcinoma

New cards
32

Hepatitis B: infection of non hepatocytes?

liver transplant does not eliminate the virus

New cards
33

Hepatitis B: vaccine

recombinant protein ("virus-like-particle" aka VLP)

New cards
34

Hepatitis B: treatment

drugs: yes (doesn't clear infection)

New cards
35

Hepatitis B: prevention

safe sex, clean needles, screen blood/blood products, decrease viral loads during birth

New cards
36

Hepatitis C: characteristics

AKA non-A, non-B +ss RNA virus enveloped human and primate hosts

New cards
37

Hepatitis C: transmission

bodily fluids: sex, blood

New cards
38

Hepatitis C: disease

acute and chronic infections Incubation: 5-50 days -initial flu-like symptoms no age effect -15-30% acute -70-85% chronic

New cards
39

Hepatitis C: Chronic infection

cirrhosis, hepatocellular carcinoma

New cards
40

Hepatitis C: infection of non-hepatocytes?

liver transplant does not eliminate the virus

New cards
41

Hepatitis C: vaccine

none

New cards
42

Hepatitis C: passive immunization

does NOT work -tremendous genetic diversity (immune resistance)

New cards
43

Hepatitis C: treatement

drugs: yes -cure infection by blocking continuous replication

New cards
44

Hepatitis C: How does chronic infection form?

results from continuous replication, not by latency

New cards
45

Hepatitis C: prevention

safe sex, screen blood/blood products, clean needles

New cards
46

Hepatitis D: characteristics

-ss RNA virus associate virus -defective (encodes no structural proteins) -utilizes Hep B for structural proteins enveloped human hosts

New cards
47

Hepatitis D: transmission

bodily fluids: sex, blood

New cards
48

Hepatitis D: disease

acute and chronic infections -acute- co-infection of B and D -acute or chronic- superinfection of B then D --chronic can result in cirrhosis no age effect

New cards
49

Hepatitis D: vaccine

none

New cards
50

Hepatitis D: treatment

drugs: none

New cards
51

Hepatitis D: prevention

Hep B vaccination -can't get D without B

New cards

Explore top notes

note Note
studied byStudied by 7 people
Updated ... ago
5.0 Stars(1)
note Note
studied byStudied by 43 people
Updated ... ago
5.0 Stars(1)
note Note
studied byStudied by 14 people
Updated ... ago
4.0 Stars(1)
note Note
studied byStudied by 139 people
Updated ... ago
5.0 Stars(1)
note Note
studied byStudied by 26 people
Updated ... ago
4.0 Stars(2)
note Note
studied byStudied by 4 people
Updated ... ago
5.0 Stars(1)
note Note
studied byStudied by 3 people
Updated ... ago
5.0 Stars(2)
note Note
studied byStudied by 10011 people
Updated ... ago
4.8 Stars(32)

Explore top flashcards

flashcards Flashcard29 terms
studied byStudied by 13 people
Updated ... ago
5.0 Stars(1)
flashcards Flashcard106 terms
studied byStudied by 15 people
Updated ... ago
5.0 Stars(1)
flashcards Flashcard154 terms
studied byStudied by 28 people
Updated ... ago
4.0 Stars(1)
flashcards Flashcard39 terms
studied byStudied by 8 people
Updated ... ago
4.0 Stars(1)
flashcards Flashcard20 terms
studied byStudied by 7 people
Updated ... ago
5.0 Stars(1)
flashcards Flashcard51 terms
studied byStudied by 10 people
Updated ... ago
5.0 Stars(2)
flashcards Flashcard29 terms
studied byStudied by 54 people
Updated ... ago
5.0 Stars(1)
flashcards Flashcard35 terms
studied byStudied by 8 people
Updated ... ago
4.0 Stars(1)